Evidence map›Paper›PMID 38864869›Full record

ArticleExperimental brain research2024

Accumulated HIIT inhibits anxiety and depression, improves cognitive function, and memory-related proteins in the hippocampus of aged rats.

Caíque Olegário Diniz E Magalhães, Ricardo Augusto Leoni De Sousa, Bruno Ferreira Mendes, Isabela Rocha Dias, Ramona Ramalho Souza Pereira, Gabriela Cruz Pereira, Kil Sun Lee, Marco Fabricio Dias Peixoto, Ricardo Cardoso Cassilhas

Abstract read
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In one paragraph

Article in Experimental brain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caíque Olegário Diniz E MagalhãesDepartment of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Diamantina, MG, CEP 39100-000, Brazil.ORCID http://orcid.org/0000-0001-7440-5463
Ricardo Augusto Leoni De SousaDepartment of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Diamantina, MG, CEP 39100-000, Brazil.ORCID http://orcid.org/0000-0003-2622-032X
Bruno Ferreira MendesDepartment of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Diamantina, MG, CEP 39100-000, Brazil.ORCID http://orcid.org/0000-0001-7904-4193
Isabela Rocha DiasDepartment of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Diamantina, MG, CEP 39100-000, Brazil.ORCID http://orcid.org/0000-0002-6372-4589
Ramona Ramalho Souza PereiraDepartment of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Diamantina, MG, CEP 39100-000, Brazil.ORCID http://orcid.org/0009-0006-6971-2366
Gabriela Cruz PereiraDepartament of Biochemistry, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.ORCID http://orcid.org/0000-0002-9477-1847
Kil Sun LeeDepartament of Biochemistry, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.ORCID http://orcid.org/0000-0002-2390-2774
Marco Fabricio Dias PeixotoDepartment of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Diamantina, MG, CEP 39100-000, Brazil.ORCID http://orcid.org/0000-0003-3324-3634
Ricardo Cardoso CassilhasDepartment of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Diamantina, MG, CEP 39100-000, Brazil. rcassilhas@yahoo.com.br.ORCID http://orcid.org/0000-0001-6970-2551

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 4384982018-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ03855-16
6 · The paper itself

Abstract

This study aimed to compare the effects of High-Intensity Interval Training (HIIT) performed in a single session(1xHIIT) versus three daily sessions (3xHIIT) on fitness level and behavior of aged rats. Eighteen-month-old Wistar rats were assigned to Untrained (UN), 1xHIIT, or 3xHIIT (n = 12/group). Both groups, 1xHIIT and 3xHIIT, performed 15 min of a treadmill running HIIT protocol during 8 weeks. 1xHIIT protocol consisted of a single daily session of 15 min, while the 3xHIIT performed three daily sessions of 5 min with a 4 h interval between the sessions. Morris Water Maze (MWM) task was used to evaluate spatial learning and memory. Splash test, Forced Swim test, and Elevated Plus Maze task (EPM) were used to evaluate anhedonic, depressive-like, and anxious behaviors, respectively. Rats were euthanized, and the hippocampus was harvested for western blot analyses (CaMKII and BDNF). Both HIIT protocols improved VO

Indexed as

AgingAnxietyBrain-Derived Neurotrophic FactorDepressionHigh-Intensity Interval TrainingHippocampusRats, WistarAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2CognitionMaleMaze LearningPhysical Conditioning, AnimalRatsSpatial MemoryBdnf protein, ratBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2CognitionMental healthMood disorderPhysical exercise

Identifiers

PMID38864869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.