Evidence map›Paper›PMID 38864759›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

HPS6 Deficiency Leads to Reduced Vacuolar-Type H

Zhenhua Hao, Huipeng Wang, Zixuan Zhou, Qingsong Yang, Beibei Zhang, Jing Ma, Wei Li

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Acidic Enough for a Healthy Breath.American journal of respiratory cell and molecular biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Zhenhua HaoBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing, China.
Huipeng WangBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing, China.
Zixuan ZhouBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing, China.
Qingsong YangBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing, China.
Beibei ZhangBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing, China.
Jing MaBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing, China.
Wei LiBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, Beijing, China.ORCID 0000-0002-0248-5510

Funding

Ministry of Science and Technology of the People's Republic of China 2019YFA0802104National Natural Science Foundation of China 32271157National Natural Science Foundation of China 32293204National Natural Science Foundation of China 92354306
6 · The paper itself

Abstract

Lamellar bodies (LBs) are tissue-specific lysosome-related organelles in type II alveolar cells that are the main site for the synthesis, storage, and secretion of pulmonary surfactants. Defects in pulmonary surfactants lead to a variety of respiratory and immune-related disorders. LB biogenesis is closely related to their function, but the underlying regulatory mechanism is largely unclear. Here, we found that deficiency of HPS6, a subunit of BLOC-2 (biogenesis of lysosome-related organelles complex-2), led to a reduction of the steady-state concentration of vacuolar-type H

Indexed as

Alveolar Epithelial CellsVacuolar Proton-Translocating ATPasesAnimalsHydrogen-Ion ConcentrationLysosomesMiceMice, Inbred C57BLMice, KnockoutOrganellesVacuolar Proton-Translocating ATPasesHermansky-Pudlak syndromeHPS6lamellar bodylysosome-related organelleV-ATPase

Identifiers

PMID38864759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.