Evidence map›Paper›PMID 38864649›Full record

ArticleMicrobiology spectrum2024

The nasal microbiota is a potential diagnostic biomarker for sepsis in critical care units.

XiLan Tan, Haiyue Liu, Wen Qiu, Zewen Li, Shuang Ge, Yuemei Luo, Nianyi Zeng, Manjun Chen, Qiqi Zhou, Shumin Cai and 5 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Bacteria and Allergic Diseases.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

XiLan Tan *Division of Infection Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-5059-3436
Haiyue Liu *Xiamen Key Laboratory of Genetic Testing, The department of laboratory medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Wen Qiu *Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zewen LiMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Shuang GeMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yuemei LuoState Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Nianyi ZengMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Manjun ChenMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Qiqi ZhouMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Shumin CaiDepartment of Intensive Care Medicine, Nanfang Hospital, Southern Medical University, Guagnzhou, China.
Jun LongMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhongran CenDivision of Intensive Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Jin SuChronic Airways Diseases Laboratory, Department of Respiratory & Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hongwei ZhouMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0003-2472-8541
Xiaolong HeMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0002-1509-8739

Funding

GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province () 2019A1515111063MOST | National Natural Science Foundation of China (NSFC) NSFC81925026MOST | National Natural Science Foundation of China (NSFC) NSFC82202629
6 · The paper itself

Abstract

This study aimed to characterize the composition of intestinal and nasal microbiota in septic patients and identify potential microbial biomarkers for diagnosis. A total of 157 subjects, including 89 with sepsis, were enrolled from the affiliated hospital. Nasal swabs and fecal specimens were collected from septic and non-septic patients in the intensive care unit (ICU) and Department of Respiratory and Critical Care Medicine. DNA was extracted, and the V4 region of the 16S rRNA gene was amplified and sequenced using Illumina technology. Bioinformatics analysis, statistical processing, and machine learning techniques were employed to differentiate between septic and non-septic patients. The nasal microbiota of septic patients exhibited significantly lower community richness (

Indexed as

BacteriaBiomarkersFecesIntensive Care UnitsMicrobiotaRNA, Ribosomal, 16SSepsisAcinetobacterAdultAgedAged, 80 and overCorynebacteriumFemaleGastrointestinal MicrobiomeHumansMachine LearningBiomarkersRNA, Ribosomal, 16S16S rRNAgut microbiotanasal microbiotasepsis

Identifiers

PMID38864649
PMCPMC11218442

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.