ArticleCirculation research2024
Therapeutic Inhibition of
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Article in Circulation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14citing papers in PubMed, 1 pooled it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Novel Quality Metrics for Assessing the Reproducibility and Translational Relevance of Mouse Transverse Aortic Constriction Experiments: A Systematic Review.Journal of the American Heart Association · 2026Pooled it
- The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure.Journal of cardiothoracic surgery · 2026Article
- The silent dialogue between cells: regulatory roles of non-coding RNAs in cardiovascular disease.Frontiers in cell and developmental biology · 2026Review
- Seeing and sensing the heart: integrating non-coding RNA biomarkers with imaging in cardiovascular medicine.European heart journal. Imaging methods and practice · 2026Review
- Article
- SMURF2 inhibition attenuates cardiac hypertrophy through blocking ubiquitination degradation of AXIN1.Acta pharmacologica Sinica · 2025Article
- ACOXL-AS1's pan-cancer dynamics and its proliferative impact on endometrial endometrioid carcinoma.BMC cancer · 2025Article
- Regulation and intervention of stem cell differentiation by long non-coding RNAs: Mechanisms and therapeutic potential.World journal of stem cells · 2025Review
- Novel insights into post-myocardial infarction cardiac remodeling through algorithmic detection of cell-type composition shifts.PLoS genetics · 2025Article
- Impact of microRNAs and long noncoding RNAs in skeletal and cardiac muscles.Current opinion in physiology · 2025Article
- Serum LncRNA PSMB8-AS1 as a novel biomarker for predicting acute coronary syndrome.Scientific reports · 2025Article
- Emerging Roles of Long Non-Coding RNAs in Cardiovascular Diseases.Journal of cellular and molecular medicine · 2025Review
- Methylations in dilated cardiomyopathy and heart failure.Frontiers in cardiovascular medicine · 2025Review
- A New linc(-RNA) Between NFAT/MEF2 and Cardiac Hypertrophy.Circulation research · 2024Article
Corrections and comments
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Authors and funding
19 authors.
Yi WangDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0002-0291-5314
Mingming ZhangDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0001-8480-0280
Rong WangDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.
Jing LinDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0009-0000-3830-485X
Qing MaSchool of Public Health, Xi'an Jiaotong University, China (J. Lin).ORCID 0000-0002-5625-1330
Haipeng GuoDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.
Huihui HuangDivision of Nephrology, Beth Israel Deaconess Medical Center (H.H.), Harvard Medical School, Boston, MA.ORCID 0000-0002-8853-8379
Zhuomin LiangDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0001-6754-9346
Yangpo CaoDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.
Xiaoran ZhangDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0003-0979-7100
Yao Wei LuDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0001-6200-2974
Jianming LiuDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.
Feng XiaoDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0002-9084-9328
Hualin YanDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0003-1338-1124
Nadya DimitrovaDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT (N.D.).ORCID 0000-0002-5983-1496
Zhan-Peng HuangDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0001-7054-655X
John D MablyCenter for Regenerative Medicine and USF Health Heart Institute, Department of Internal Medicine, University of South Florida, Tampa (J.D.M., D.-Z.W.).ORCID 0000-0002-3626-9090
William T PuDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0002-4551-8079
Da-Zhi WangDepartment of Cardiology, Boston Children's Hospital (Y.W., M.Z., R.W., J. Lin, Q.M., H.G., Z.L., Y.C., X.Z., Y.W.L., J. Liu, F.X., H.Y., Z.-P.H., W.T.P., D.-Z.W.), Harvard Medical School, Boston, MA.ORCID 0000-0003-1774-6549
Funding
RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0MEpsin in Angiogenesis and Vascular RemodelingR01HL093242 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI CHEN, HONG, WANG, DA-ZHI · 2009 to 2021
$7.3MMolecular Mechanisms Controlling Lymphatic Vascular Function in Health and DiseaseR01HL133216 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, DIXON, JAMES BRANDON · 2016 to 2025
$6.7MCD45-mediated endothelial-to-mesenchymal transition in cardiovascular diseaseR01HL141853 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, WANG, DA-ZHI · 2020 to 2023
$3.3MMOLECULAR MECHANISMS OF DYSTROPHIC CARDIOMYOPATHYR01HL149401 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI WANG, DA-ZHI · 2019 to 2022
$2.3MFunction and Mechanism of the Intercalated Disc Protein XinB in Cardiomyocyte Proliferation and Cardiac RegenerationR01HL168900 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Da-Zhi Wang · 2023 to 2026
$2.2MlncRNA Function and Mechanisms during Cardiac Development and DiseaseR01HL165794 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Da-Zhi Wang · 2023 to 2026
$2.2MMicroRNAs, cardiac function and cardiomyopathyR01HL138757 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI WANG, DA-ZHI · 2017 to 2020
$2.1MTherapeutic applications of miRNAs in myocardial and cardiac regenerationR01HL125925 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WANG, DA-ZHI · 2016 to 2019
$1.8MMolecular Mechanisms of Dilated CardiomyopathyR01HL116919 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WANG, DA-ZHI · 2013 to 2016
$1.7MNHLBI NIH HHS R01 HL093242NHLBI NIH HHS R01 HL116919NHLBI NIH HHS R01 HL125925NHLBI NIH HHS R01 HL133216NHLBI NIH HHS R01 HL138757NHLBI NIH HHS R01 HL141853NHLBI NIH HHS R01 HL149401NHLBI NIH HHS R01 HL165794NHLBI NIH HHS R01 HL168900NHLBI NIH HHS T32 HL007572
Abstract
backgroundCardiac hypertrophy is an adaptive response to pressure overload aimed at maintaining cardiac function. However, prolonged hypertrophy significantly increases the risk of maladaptive cardiac remodeling and heart failure. Recent studies have implicated long noncoding RNAs in cardiac hypertrophy and cardiomyopathy, but their significance and mechanism(s) of action are not well understood.
methodsWe measured
results
conclusionsThese findings advance our understanding of the functional significance of stress-induced long noncoding RNA in cardiac hypertrophy and demonstrate the potential of
Indexed as
CardiomegalyMice, KnockoutRNA, Long NoncodingAnimalsCardiomyopathy, DilatedHumansMaleMiceMice, Inbred C57BLMyocytes, CardiacVentricular RemodelinglincRNA-p21, mouseRNA, Long Noncodinggene expression profilingheart failurehypertrophyRNA, long noncodingventricular remodeling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.