Evidence map›Paper›PMID 38864136›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2024

[Role and mechanism of cysteine and glycine-rich protein 2 in the malignant progression of neuroblastoma].

Yao Zhang, Jinxin Guo, Shijia Zhan, Enyu Hong, Hui Yang, Anna Jia, Yan Chang, Yongli Guo, Xuan Zhang

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yao ZhangNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.
Jinxin GuoNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.
Shijia ZhanNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.
Enyu HongNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.
Hui YangNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.
Anna JiaNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.
Yan ChangNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.
Yongli GuoNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.
Xuan ZhangNational Center for Children's Health; Beijing Children's Hospital, Capital Medical University; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Pediatric Research Institute; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery; Beijing 100045, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the function and underlying mechanism of cysteine and glycine-rich protein 2 (CSRP2) in neuroblastoma (NB).

methodsThe correlation between the expression level of

resultsBy analyzing the NB clinical sample databases, it was found that the expression levels of

conclusionCSRP2 is highly expressed in high-risk NB with 3/4 INSS stages, and the expression levels of CSRP2 are negatively correlated with the overall survival of NB patients. CSRP2 significantly increased the proliferation and cell migration of NB cells and inhibited cell apoptosis via the activation of ERK1/2. All these results indicate that CSRP2 promotes the progression of NB by activating ERK1/2, and this study will provide a potential target for high-risk NB therapy.

Indexed as

ApoptosisCell MovementCell ProliferationNeuroblastomaCell CycleCell Line, TumorDisease ProgressionHumansKi-67 AntigenPrognosisRNA, MessengerRNA, Small InterferingSerine-Arginine Splicing FactorsKi-67 AntigenRNA, MessengerRNA, Small InterferingSerine-Arginine Splicing FactorsCell migrationCell proliferationCysteine and glycine-rich protein 2Extracellular signal-regulated kinase 1/2Neuroblastoma

Identifiers

PMID38864136
PMCPMC11167550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.