Evidence map›Paper›PMID 38864135›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2024

[Ursolic acid improved demyelination and interstitial fluid drainage disorders in schizophrenia mice].

Ren Long, Xin Mao, Tianzi Gao, Qian Xie, Hanbo Tan, Ziyin Li, Hongbin Han, Lan Yuan

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ren LongDepartment of Medical Imaging Technology, Institute of Medical Technology, Peking University & Beijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Xin MaoDepartment of Radiology, Peking University Third Hispital, Beijing 100191, China.
Tianzi GaoDepartment of Medical Imaging Technology, Institute of Medical Technology, Peking University & Beijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Qian XieDepartment of Nephrology, Peking University Third Hispital, Beijing 100191, China.
Hanbo TanDepartment of Medical Imaging Technology, Institute of Medical Technology, Peking University & Beijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Ziyin LiDepartment of Medical Imaging Technology, Institute of Medical Technology, Peking University & Beijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Hongbin HanDepartment of Medical Imaging Technology, Institute of Medical Technology, Peking University & Beijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Lan YuanDepartment of Medical Imaging Technology, Institute of Medical Technology, Peking University & Beijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo unveil the pathological changes associated with demyelination in schizophrenia (SZ) and its consequential impact on interstitial fluid (ISF) drainage, and to investigate the therapeutic efficacy of ursolic acid (UA) in treating demyelination and the ensuing abnormalities in ISF drainage in SZ.

methodsFemale C57BL/6J mice, aged 6-8 weeks and weighing (20±2) g, were randomly divided into three groups: control, SZ model, and UA treatment. The control group received intraperitoneal injection (ip) of physiological saline and intragastric administration (ig) of 1% carboxymethylcellulose sodium (CMC-Na). The SZ model group was subjected to ip injection of 2 mg/kg dizocilpine maleate (MK-801) and ig administration of 1% CMC-Na. The UA treatment group underwent ig administration of 25 mg/kg UA and ip injection of 2 mg/kg MK-801. The treatment group received UA pretreatment via ig administration for one week, followed by a two-week drug intervention for all the three groups. Behavioral assessments, including the open field test and prepulse inhibition experiment, were conducted post-modeling. Subsequently, changes in the ISF partition drainage were investigated through fluorescent tracer injection into specific brain regions. Immunofluorescence analysis was employed to examine alterations in aquaporin 4 (AQP4) polarity distribution in the brain and changes in protein expression. Myelin reflex imaging using Laser Scanning Confocal Microscopy (LSCM) was utilized to study modifications in myelin within the mouse brain. Quantitative data underwent one-way ANOVA, followed by TukeyHSD for post hoc pairwise comparisons between the groups.

resultsThe open field test revealed a significantly longer total distance [(7 949.39±1 140.55) cm

conclusionUA intervention ameliorates behavioral performance in SZ mice, Thus alleviating hyperactivity and anxiety symptoms and restoring sensorimotor gating function. The underlying mechanism may involve the improvement of demyelination and ISF drainage dysregulation in SZ mice.

Indexed as

Demyelinating DiseasesDisease Models, AnimalExtracellular FluidMice, Inbred C57BLSchizophreniaTriterpenesUrsolic AcidAnimalsAquaporin 4Dizocilpine MaleateFemaleMiceAquaporin 4Dizocilpine MaleateTriterpenesUrsolic AcidBrain interstitial fluidDemyelinationSchizophreniaUrsolic acid

Identifiers

PMID38864135
PMCPMC11167553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.