Evidence map›Paper›PMID 38863977›Full record

ArticleFrontiers in pharmacology2024

The association between HLA-B variants and amoxicillin-induced severe cutaneous adverse reactions in Chinese han population.

Ting Wang, Jin Yang, Fanping Yang, Ye Cheng, Zichong Huang, Bei Li, Linlin Yang, Qinghe Xing, Xiaoqun Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Real-World Data on Severe Cutaneous Adverse Reactions to Drugs.Pharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ting Wang *Children's Hospital of Fudan University, Institutes of Biomedical Sciences of Fudan, Shanghai, China.
Jin Yang *Department of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai, China.
Fanping YangDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai, China.
Ye ChengChildren's Hospital of Fudan University, Institutes of Biomedical Sciences of Fudan, Shanghai, China.
Zichong HuangCollege of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou, China.
Bei LiChildren's Hospital of Fudan University, Institutes of Biomedical Sciences of Fudan, Shanghai, China.
Linlin YangDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Qinghe XingChildren's Hospital of Fudan University, Institutes of Biomedical Sciences of Fudan, Shanghai, China.
Xiaoqun LuoDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Amoxicillin (AMX) is among the most prescribed and the best tolerated antimicrobials worldwide. However, it can occasionally trigger severe cutaneous adverse reactions (SCAR) with a significant morbidity and mortality. The genetic factors that may be relevant to AMX-induced SCAR (AMX-SCAR) remain unclear. Identification of the genetic risk factor may prevent patients from the risk of AMX exposure and resume therapy with other falsely implicated drugs. Methodology: Four patients with AMX-SCAR, 1,000 population control and 100 AMX-tolerant individuals were enrolled in this study. Both exome-wide and HLA-based association studies were conducted. Molecular docking analysis was employed to simulate the interactions between AMX and risk HLA proteins. Results: Compared with AMX-tolerant controls, a significant association of Conclusion: Our findings suggest that genetic susceptibility may be involved in the development of AMX-SCAR in Han Chinese. However, whether the HLA-B variants observed in this study can be used as an effective genetic marker of AMX-induced SCAR still needs to be further explored in larger cohort studies and other ethnic populations.

Indexed as

amoxicillinHLA-Bsevere cutaneous adverse reactionsvariantswhole-exome sequencing

Identifiers

PMID38863977
PMCPMC11165025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.