ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2024
Trends in Shortages of Lead Chelators From 2001 to 2022.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Small Doses, Big Problems: Antidote Shortages.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Acute Copper Toxicity: Succimer Makes you Less Blue.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026Article
- Article
- Lead Exposure in Children: Failure to Protect the Most Vulnerable.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
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Authors and funding
6 authors.
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Abstract
objectiveThe study aims to describe drug shortages affecting lead chelators in the United States from 2001 through 2022.
methodsDrug shortage data were retrieved from the University of Utah Drug Information Service from January 1, 2001, through December 31, 2022. Shortages of first- and second-line lead chelators were analyzed. Drug class, formulation, administration route, shortage reason, shortage duration, generic status, single-source status, and presence of temporally overlapping shortages were examined. Total shortage months, percentages of study period on shortage, and median shortage durations were calculated.
resultsThirteen lead chelator shortages were reported during the study period. Median duration was 7.4 months and the longest shortage (24.8 months) involved calcium disodium edetate. Calcium disodium edetate and dimercaprol had the greatest number of shortages, 4 each, and 61.5% of shortages involved parenteral medications. Median shortage duration was 14.2 months for parenteral agents and 2.2 months for non-parenteral agents. All shortages involved generic, single-source products. Supply/demand and manufacturing problems were the most common shortage reasons provided. Overlapping shortages occurred for 3.7% of the study period. Median shortage duration increased from 3 to 11 months in the second half of the study period, and 61.5% of shortages occurred in the second half of the study period.
conclusionsAll chelators experienced multiple shortages, which became increasingly frequent and prolonged over time. Concurrent shortages occurred, potentially hampering substitution between different agents. Health care stakeholders must build supply chain resilience and develop guidelines regarding how to modify chelation therapy based on shortage conditions.
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