ArticleFrontiers in aging neuroscience2024
The characteristics of brain atrophy prior to the onset of Alzheimer's disease: a longitudinal study.
Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Mapping the evolution of dual-task paradigms in cognitive aging: A bibliometric analysis of research landscapes and translational applications.GeroScience · 2026Review
- Longitudinal associations between albuminuria and renal function and annual brain volume changes: the Ohasama study.Clinical and experimental nephrology · 2026Article
- Associations between ventricular boundary shift integral and composite cognitive domains across the alzheimer's disease continuum.Scientific reports · 2026Article
- Frontal Lobe and Subregional Volumetric Alterations Across Alzheimer's Disease, Amnestic Mild Cognitive Impairment, and Vascular Dementia: An MRI Volumetry Study.Brain sciences · 2026Article
- Region-dependent mechanical parameters in simulating cerebral atrophy.APL bioengineering · 2026Article
- Brain Volume Alterations and Cognitive Functions in Patients with Common Variable Immunodeficiency: Evaluating the Impact of Autoimmunity.Journal of clinical medicine · 2026Article
- Target-level convergence of directional prefrontal connectivity across Alzheimer's disease stages: an fNIRS study.Frontiers in aging neuroscience · 2026Article
- Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.Journal of cachexia, sarcopenia and muscle · 2025Article
- The Association between the rs6656401 Locus of the CR1 Gene and Structural Alterations of Brain Effects in Han Chinese Patients with Alzheimer's Disease.Current Alzheimer research · 2025Article
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3 authors.
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Abstract
Objective: We aimed to use the onset time of Alzheimer's disease (AD) as the reference time to longitudinally investigate the atrophic characteristics of brain structures prior to the onset of AD. Materials and methods: A total of 328 participants from the ADNI database with clear onset of AD and structural imaging data were included in our study. The time before the onset of AD (abbreviated as BAD) was calculated. We investigated the longitudinal brain changes in 97 regions using multivariate linear mixed effects regression models. Results: The average BAD was -28.15 months, with a range from -156 to 0 months. The 54 brain regions showed significant atrophy prior to the onset of AD, and these regions were mainly distributed in the frontal and temporal lobes. The parietal and occipital lobe exhibited relatively less atrophy than the other brain lobes. Sex, age, and magnetic field strength had greater direct impacts on structural indicators than APOE genotype and education. The analysis of interaction effects revealed that the APOE ε4 mutation carriers exhibited more severe structural changes in specific brain regions as the BAD increased. However, sex, age, and education had minimal regulatory influence on the structural changes associated with BAD. Conclusion: Longitudinal analysis, with the onset time point of AD as the reference, can accurately describe the features of structural changes preceding the onset of AD and provide a comprehensive understanding of AD development.
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