Prefrontal activity and heart rate variability during cognitive tasks may show different changes in young and older adults with and without mild cognitive impairment.

Pei-Hsin Ku, Yea-Ru Yang, Nai-Chen Yeh, Pei-Yun Li, Chia-Feng Lu, Ray-Yau Wang

Abstract read

In one paragraph

Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Prefrontal hemodynamic alterations during resting state and stroop interference in cognitively healthy older adults with high plasma pTau-217 levels.Neuroimage. Reports · 2026
Article
Proteomic associations with cognitive variability as measured by the Wisconsin Card Sorting Test in a healthy Thai population: A machine learning approach.PloS one · 2025
Article
Cognitive Impairment and Synaptic Dysfunction in Cardiovascular Disorders: The New Frontiers of the Heart-Brain Axis.Biomedicines · 2024
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5 · Who and what money

Authors and funding

6 authors.

Pei-Hsin KuDepartment of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Yea-Ru YangDepartment of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Nai-Chen YehDepartment of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Pei-Yun LiDepartment of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Chia-Feng LuDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Ray-Yau WangDepartment of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Age-related decline in cognitive function is often linked to changed prefrontal cortex (PFC) activity and heart rate variability (HRV). Mild cognitive impairment (MCI), a transitional stage between normal aging and dementia, might have further degeneration beyond aging. This study aimed to investigate the differences between young and older adults with or without MCI in cognitive functions, task-induced PFC activation and HRV changes. Methods: Thirty-one healthy young adults (YA), 44 older adults (OA), and 28 older adults with MCI (OA-MCI) were enrolled and compared in this cross-sectional study. Each participant received a one-time assessment including cognitive and executive functions, as well as the simultaneous recording of PFC activity and HRV during a cognitive task paradigm. Results: We observed age-related decrease in global cognitive functions, executive functions, HRV, and increase in PFC activity. The MCI further deteriorated the global cognitive and executive performances, but not the HRV or the prefrontal activation. Conclusion: Older people showed lower performances in general cognitive function and executive function, compensatory increase of PFC activity, and reduced HRV. Older people with MCI had further deterioration in cognitive performance, but not in PFC activation and HRV.

Indexed as

agingcognitive functionexecutive functionheart rate variabilitymild cognitive impairmentprefrontal cortex

Identifiers

PMID38863782

DOI10.3389/fnagi.2024.1392304

PMCPMC11166260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.