Evidence map›Paper›PMID 38863725›Full record

ArticleUpsala journal of medical sciences2024

Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging.

Tobias Gustavsson, Matthias M Herth, Dag Sehlin, Stina Syvänen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Upsala journal of medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Radionuclide Selection Influences Imaging Outcomes in Immuno-PET with a Brain-Penetrating Anti-Amyloid-β Antibody.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025
    Review
  4. Article
  5. Nuclear Imaging of Bispecific Antibodies on the Rise.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tobias GustavssonDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Matthias M HerthDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Dag SehlinDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Stina SyvänenDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The development of bispecific antibodies that can traverse the blood-brain barrier has paved the way for brain-directed immunotherapy and when radiolabelled, immunoPET imaging. The objective of this study was to investigate how indium-111 ( Methods: Bispecific RmAb158-scFv8D3 (biAb) was radiolabelled with Results: All three [ Conclusions: The successful

Indexed as

Amyloid beta-PeptidesBrainIndium RadioisotopesTomography, Emission-Computed, Single-PhotonAlzheimer DiseaseAnimalsAntibodies, BispecificBlood-Brain BarrierMiceMice, TransgenicRadiopharmaceuticalsReceptors, TransferrinTissue DistributionAmyloid beta-PeptidesAntibodies, BispecificIndium-111Indium RadioisotopesRadiopharmaceuticalsReceptors, TransferrinAmyloid-betaantibodyIndium-111SPECT imaging

Identifiers

PMID38863725
PMCPMC11165248

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.