Evidence map›Paper›PMID 38863702›Full record

ArticleFrontiers in immunology2024

Immunization with PfGBP130 generates antibodies that inhibit RBC invasion by

Yannick Johnson, Ahmad Rushdi Shakri, Sunthorn Pond-Tor, Anup Jnawali, Tanbir Najrana, Haiwei Wu, Jhasketan Badhai, Mohamad-Gabriel Alameh, Drew Weissman, Edward Kabyemela and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yannick JohnsonDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, United States.
Ahmad Rushdi ShakriDepartment of Internal Medicine, University of South Florida, Tampa, FL, United States.
Sunthorn Pond-TorDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, United States.
Anup JnawaliDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, United States.
Tanbir NajranaDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, United States.
Haiwei WuDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, United States.
Jhasketan BadhaiDepartment of Internal Medicine, University of South Florida, Tampa, FL, United States.
Mohamad-Gabriel AlamehDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Drew WeissmanDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Edward KabyemelaDepartment of Pathology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Patrick DuffyLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.
Michal FriedLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.
Jonathan Kurtis *Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, United States.
Dipak Kumar Raj *Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, United States.

Funding

Malaria Pathogenesis in young children and vaccine discoveryZIAAI001134 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2010 to 2025
$11.3M
Tfh responses to novel vaccine candidates and protection from pediatric falciparum malariaR01AI127699 · NIAID · BROWN UNIVERSITY · PI KURTIS, JONATHAN D. · 2017 to 2021
$3.4M
PfSEA-1 based vaccines for falciparum malariaR01AI110699 · NIAID · RHODE ISLAND HOSPITAL · PI KURTIS, JONATHAN D. · 2014 to 2018
$2.7M
Targeted Vaccine Development for Pediatric Falciparum MalariaR01AI076353 · NIAID · RHODE ISLAND HOSPITAL · PI KURTIS, JONATHAN D. · 2008 to 2011
$2.4M
Multi-target blood stage vaccine against Plasmodium falciparumR01AI144014 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI RAJ, DIPAK KUMAR · 2020 to 2025
$1.9M
Identifying the targets of protective immunity to severe falciparum malariaR56AI173140 · NIAID · BROWN UNIVERSITY · PI KURTIS, JONATHAN D. · 2023 to 2023
$500k
NIAID NIH HHS R01 AI076353NIAID NIH HHS R01 AI110699NIAID NIH HHS R01 AI127699NIAID NIH HHS R01 AI144014NIAID NIH HHS R56 AI173140
6 · The paper itself

Abstract

Background: Despite decades of effort, Methods and results: To discover new vaccine candidates, we used our whole proteome differential screening method and identified PfGBP130 as a parasite protein uniquely recognized by antibodies from children who had developed resistance to Conclusion: We are currently advancing PfGBP130-A formulated as a lipid-encapsulated mRNA for efficacy evaluation in non-human primates.

Indexed as

Antibodies, ProtozoanErythrocytesMalaria, FalciparumMalaria VaccinesPlasmodium falciparumProtozoan ProteinsAnimalsAntigens, ProtozoanFemaleHumansImmunizationMiceAntibodies, ProtozoanAntigens, ProtozoanMalaria VaccinesProtozoan Proteinsblood stage malaria antigengrowth inhibiting activitymalariamRNAPlasmodium falciparumvaccine

Identifiers

PMID38863702
PMCPMC11165087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.