Evidence map›Paper›PMID 38863647›Full record

ArticleInternational journal of nanomedicine2024

Resveratrol-Ampicillin Dual-Drug Loaded Polyvinylpyrrolidone/Polyvinyl Alcohol Biomimic Electrospun Nanofiber Enriched with Collagen for Efficient Burn Wound Repair.

Shubham Kanaujiya, Dilip Kumar Arya, Prashant Pandey, Sneha Singh, Giriraj Pandey, Shabnam Anjum, Md Meraj Anjum, Daoud Ali, Saud Alarifi, Vijayakumar Mr and 3 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Multifunctional Electrospun PCL/Starch/n-AlInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Adoption of polyvinyl alcohol electrospinning materials for skin wound dressing.Journal of materials science. Materials in medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shubham Kanaujiya *Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.ORCID 0009-0001-0277-2130
Dilip Kumar Arya *Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Prashant PandeyDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.ORCID 0000-0003-0700-914X
Sneha SinghDepartment of Chemical Engineering, IIT Kanpur, Kanpur, India.
Giriraj PandeyDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Shabnam AnjumDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang, Liaoning, 110122, People's Republic of China.
Md Meraj AnjumDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Daoud AliDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0002-1045-4984
Saud AlarifiDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0001-9824-5089
Vijayakumar MrDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Sri SivakumarDepartment of Chemical Engineering, IIT Kanpur, Kanpur, India.
Saurabh SrivastavaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.
P S RajinikanthDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.ORCID 0000-0002-1000-4211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The healing of burn wounds is a complicated physiological process that involves several stages, including haemostasis, inflammation, proliferation, and remodelling to rebuild the skin and subcutaneous tissue integrity. Recent advancements in nanomaterials, especially nanofibers, have opened a new way for efficient healing of wounds due to burning or other injuries. Methods: This study aims to develop and characterize collagen-decorated, bilayered electrospun nanofibrous mats composed of PVP and PVA loaded with Resveratrol (RSV) and Ampicillin (AMP) to accelerate burn wound healing and tissue repair. Results: Nanofibers with smooth surfaces and web-like structures with diameters ranging from 200 to 400 nm were successfully produced by electrospinning. These fibres exhibited excellent in vitro properties, including the ability to absorb wound exudates and undergo biodegradation over a two-week period. Additionally, these nanofibers demonstrated sustained and controlled release of encapsulated Resveratrol (RSV) and Ampicillin (AMP) through in vitro release studies. The zone of inhibition (ZOI) of PVP-PVA-RSV-AMP nanofibers against Conclusion: The RSV and AMP-loaded nanofiber mats, developed in this study, expedite burn wound healing through their multifaceted approach.

Indexed as

AmpicillinBurnsCollagenNanofibersResveratrolWound HealingAnimalsAnti-Bacterial AgentsBiofilmsEscherichia coliHumansMalePolyvinyl AlcoholPovidoneRatsStaphylococcus aureusAmpicillinAnti-Bacterial AgentsCollagenPolyvinyl AlcoholPovidoneResveratrolampicillinburn wound healingcollagenelectrospinningnanofiberresveratrol

Identifiers

PMID38863647
PMCPMC11164821

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.