ArticleFrontiers in genetics2024
Molecular epidemiology of dengue in Malaysia: 2015-2021.
Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Arboviral infections of the central nervous system: Mechanisms of invasion and long-term consequences.Journal of neurovirology · 2026Review
- Multicenter evaluation of a single-device dengue antibody/antigen rapid test for simultaneous detection of NS1, IgM, and IgG.Microbiology spectrum · 2026Article
- Community participation and technological innovation: Baseline qualitative insights to inform a five-year cohort on drone-based dengue surveillance in Malaysia.PLoS neglected tropical diseases · 2026Article
- Sociodemographic determinants of willingness to adopt surveillance technology and mosquito control training for dengue in Malaysia.Scientific reports · 2026Article
- Genomic analysis and molecular profiling of dengue viruses in Sabah, Malaysia during 2019-2020.IJID regions · 2025Article
- Understanding the future of dengue in Malaysia: Assessing knowledge, attitude, and homeowner practices in mitigating climate-driven risks.F1000Research · 2024Article
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Authors and funding
13 authors.
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Abstract
Dengue has been one of the major public health problems in Malaysia for decades. Over 600,000 dengue cases and 1,200 associated fatalities have been reported in Malaysia from 2015 to 2021, which was 100% increase from the cumulative total of dengue cases reported during the preceding 07-year period from 2008 to 2014. However, studies that describe the molecular epidemiology of dengue in Malaysia in recent years are limited. In the present study, we describe the genetic composition and dispersal patterns of Dengue virus (DENV) by using 4,004 complete envelope gene sequences of all four serotypes (DENV-1 = 1,567, DENV-2 = 1,417, DENV-3 = 762 and DENV-4 = 258) collected across Malaysia from 2015 to 2021. The findings revealed that DENV populations in Malaysia were highly diverse, and the overall heterogeneity was maintained through repetitive turnover of genotypes. Phylogeography analyses suggested that DENV dispersal occurred through an extensive network, mainly among countries in South and East Asia and Malaysian states, as well as among different states, especially within Peninsular Malaysia. The results further suggested Selangor and Johor as major hubs of DENV emergence and spread in Malaysia.
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