ArticleAmerican journal of hypertension2024
High Blood Pressure Is Associated With Lower Brain Volume and Cortical Thickness in Healthy Young Adults.
Article in American journal of hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The role of metabolic health in neurostructural and cognitive alterations in bipolar disorders.Psychological medicine · 2026Article
- Metabolic, demographic, and behavioral risk factors predict brain structural variability in the general population: an analysis of the human connectome project young adults.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Prospective observational study of brain magnetic resonance imaging in adolescents with primary hypertension.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Neuroendocrine-vascular interaction is associated with thalamocortical disorganization and cognitive decline in perimenopausal hypertension.Frontiers in medicine · 2026Article
- No associations between blood pressure and brain volumes in a convenience sample of Hispanic/Latino middle-aged and older adults.Frontiers in aging neuroscience · 2026Article
- Associations of Blood Pressure Level and Variability With Cortical Thickness: A Cross-Sectional Analysis From the Maracaibo Aging Study.American journal of hypertension · 2026Article
- Associations of Central Arterial Stiffness With Brain White Matter Integrity and Gray Matter Volume in MRI Across the Adult Lifespan.Journal of magnetic resonance imaging : JMRI · 2025Article
- Association of early life cardiovascular risk factors with grey matter structure in young adults in the United Kingdom: the ALSPAC study.EBioMedicine · 2024Article
- A prior-sampling conditional variational autoencoder for neuroimaging normative modelling: Benchmarking deep learning against statistical approaches.Imaging neuroscience (Cambridge, Mass.)Article
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5 authors.
Funding
Abstract
backgroundHigh blood pressure (BP) in middle-aged and older adults is associated with lower brain volume and cortical thickness assessed with structural magnetic resonance imaging (MRI). However, little evidence is available on young adults. We investigated the associations of high BP with brain volumes and cortical thickness in healthy young adults.
methodsThis cross-sectional study included 1,095 young adults (54% women, 22-37 years) from the Human Connectome Project (HCP) who self-reported not having a history of hypertension or taking antihypertensive medications. Brachial systolic (SBP) and diastolic BP (DBP) were measured with a semi-automatic or manual sphygmomanometer during study visits. Structural MRI was used to measure gray matter (GM) and white matter (WM) volume and mean cortical thickness. Associations of BP and hypertension stage with total and regional brain volumes and cortical thickness were analyzed using linear regression and analysis of covariance (ANCOVA) after adjusting for age, sex, education years, body mass index (BMI), smoking, alcohol consumption history, zygosity, and total intracranial volume.
resultsSBP and DBP were (mean ± SD) 123.6 ± 14.2 and 76.5 ± 10.6 mm Hg, respectively, (n = 1,095). High DBP was associated with lower total GM (P = 0.012), cortical GM (P = 0.004), subcortical GM (P = 0.012), and total WM volumes (P = 0.031). High SBP and DBP were associated with lower regional cortical volume and cortical thickness.
conclusionsThese findings suggest that high BP may have deleterious effects on brain health at the early stage of adulthood.
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