Evidence map›Paper›PMID 38863007›Full record

ArticleTranslational neurodegeneration2024

DOPA-decarboxylase is elevated in CSF, but not plasma, in prodromal and de novo Parkinson's disease.

Ellen Appleton, Shervin Khosousi, Michael Ta, Michael Nalls, Andrew B Singleton, Andrea Sturchio, Ioanna Markaki, Wojciech Paslawski, Hirotaka Iwaki, Per Svenningsson

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neurodegeneration, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ellen Appleton *Laboratory of Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Shervin Khosousi *Laboratory of Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Michael TaCenter for Alzheimer's and Related Dementias, National Institute On Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Michael NallsCenter for Alzheimer's and Related Dementias, National Institute On Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Andrew B SingletonCenter for Alzheimer's and Related Dementias, National Institute On Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Andrea SturchioLaboratory of Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ioanna MarkakiLaboratory of Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Wojciech PaslawskiLaboratory of Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Hirotaka IwakiCenter for Alzheimer's and Related Dementias, National Institute On Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Per SvenningssonLaboratory of Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. per.svenningsson@ki.se.ORCID 0000-0001-6727-3802

Funding

Knut och Alice Wallenbergs Stiftelse 2022Kommunfullmäktige, Stockholms Stad 2019NHLBI Division of Intramural Research NIAScience for Life Laboratory 2022
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Dopa DecarboxylaseParkinson DiseaseProdromal SymptomsAgedBiomarkersFemaleHumansMaleMiddle AgedBiomarkersDopa Decarboxylase

Identifiers

PMID38863007
PMCPMC11165760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.