Evidence map›Paper›PMID 38862881›Full record

ArticleBMC infectious diseases2024

Regional differences of Mycobacterium tuberculosis complex infection and multidrug resistance epidemic in Luoyang.

Zhenzhen Wang, Tengfei Guo, Liyang Xu, Jinwei Liu, Yi Hou, Junrong Jin, Qing Zhang, Tao Jiang, Zhanqin Zhao, Yun Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhenzhen WangThe First Affiliated Hospital and Clinical Medical College, Henan University of Science and Technology, Luoyang, China.
Tengfei GuoThe First Affiliated Hospital and Clinical Medical College, Henan University of Science and Technology, Luoyang, China.
Liyang XuLuoyang Center for Disease Control and Prevention, Luoyang, China.
Jinwei LiuThe First Affiliated Hospital and Clinical Medical College, Henan University of Science and Technology, Luoyang, China.
Yi HouLuoyang Center for Disease Control and Prevention, Luoyang, China.
Junrong JinThe First Affiliated Hospital and Clinical Medical College, Henan University of Science and Technology, Luoyang, China.
Qing ZhangThe First Affiliated Hospital and Clinical Medical College, Henan University of Science and Technology, Luoyang, China.
Tao JiangThe First Affiliated Hospital and Clinical Medical College, Henan University of Science and Technology, Luoyang, China.
Zhanqin ZhaoCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China. zhaozhanqin@126.com.
Yun XueSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China. xueyun6688@163.com.

Funding

Joint construction project of Henan Province LHGJ20200589National Nature Science Foundation of China 32072899
6 · The paper itself

Abstract

backgroundTuberculosis (TB) remains a global public health event of great concern, however epidemic data on TB covering entire areas during the special period of the COVID-19 epidemic have rarely been reported. We compared the dissemination and multidrug-resistance patterns of Mycobacterium tuberculosis complex (MTBC) in the main urban area of Luoyang City, China (including six municipal jurisdictions) and nine county and township areas under its jurisdiction, aimed to establish the epidemiology of TB in this region and to provide reference for precision anti-TB in places with similar settings.

methodsFrom 2020 to 2022, sputum samples were collected from 18,504 patients with confirmed, suspected and unexcluded TB in 10 designated TB medical institutions. Insertion sequence 6110 was amplified by PCR (rpoB gene detection if necessary) to confirm the presence of MTBC. PCR-positive specimens were analyzed by multicolor melting curve analysis to detect multidrug resistance.

resultsAmong the 18,504 specimens, 2675 (14.5%) were MTBC positive. The positive rate was higher in the main urban area than in the county and township areas (29.8% vs. 10.9%, p < 0.001). Male, re-treated and smear-positive groups were high-burden carriers of MTBC. Individuals aged > 60 years were the largest group infected with MTBC in the main urban area, compared with individuals aged < 61 years in the county and township areas. The detection of multidrug-resistant TB (MDR-TB) was higher in the main urban area than in the county and township areas (13.9% vs. 7.8%, p < 0.001). In all areas, MDR-TB groups were dominated by males, patients with a history of TB treatment, and patients aged < 61 years. Stratified analysis of MDR-TB epidemiology showed that MDR4 (INH þ RIF þ EMB þ SM) was predominant in the main urban area, while MDR3 (INH þ RIF þ SM) was predominant in the county and township areas. MDR-TB detection rate and epidemiology differed among the county and township areas.

conclusionsFor local TB control, it is necessary to plan more appropriate and accurate prevention and control strategies according to the regional distribution of MTBC infection.

Indexed as

COVID-19Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantAdolescentAdultAgedAged, 80 and overAntitubercular AgentsChildChild, PreschoolChinaDrug Resistance, Multiple, BacterialEpidemicsFemaleHumansInfantAntitubercular AgentsMultidrug resistanceMycobacterium tuberculosis complexRegional differencesTuberculosis

Identifiers

PMID38862881
PMCPMC11167740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.