Evidence map›Paper›PMID 38862870›Full record

ArticleThe AAPS journal2024

Pioneering Topical Ointment Intervention for Unprecedented Antimicrobial and Diabetic Wound Management with Phenylpropanoids and Nano-Silver.

Hari Prasath Nagaiah, Priya Dharsini Periyakaruppan Murugesan, Chaughule Vrushali Ravindra Rupali, Karutha Pandian Shunmugiah

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Article in The AAPS journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Hari Prasath NagaiahDepartment of Biotechnology, Alagappa University, Karaikudi, India.
Priya Dharsini Periyakaruppan MurugesanDepartment of Biotechnology, Alagappa University, Karaikudi, India.
Chaughule Vrushali Ravindra RupaliDepartment of Biotechnology, Alagappa University, Karaikudi, India.
Karutha Pandian ShunmugiahDepartment of Biotechnology, Alagappa University, Karaikudi, India. pandiansk@alagappauniversity.ac.in.ORCID 0000-0003-2925-0575

Funding

Indian Council of Medical Research 3/1/2/4/SRF/Trauma/2022/NCD-1Indian Council of Medical Research Date:26/12/2022 [Proposal ID:2021-12933]Rashtriya Uchchatar Shiksha Abhiyan Dept of EdnRashtriya Uchchatar Shiksha Abhiyan F. 24-51/2014-URashtriya Uchchatar Shiksha Abhiyan GOIRashtriya Uchchatar Shiksha Abhiyan Policy (TN Multi-Gen)
6 · The paper itself

Abstract

Addressing the intertwined challenges of antimicrobial resistance and impaired wound healing in diabetic patients, an oil/water emulsion-based nano-ointment integrating phenylpropanoids-Eugenol and Cinnamaldehyde-with positively-charged silver nanoparticles was synthesized. The process began with the synthesis and characterization of nano-silver, aimed at ensuring the effectiveness and safety of the nanoparticles in biological applications. Subsequent experiments determined the minimum inhibitory concentration (MIC) against pathogens such as Streptococcus aureus, Pseudomonas aeruginosa and Candida albicans. These MIC values of all three active leads guided the strategic formulation of an ointment base, which effectively integrated the bioactive components. Evaluations of this nano-ointment revealed enhanced antimicrobial activity against both clinical and reference bacterial strains and it maintained stability after freeze-thaw cycles. Furthermore, the ointment demonstrated superior in-vitro diabetic wound healing capabilities and significantly promoted angiogenesis, as shown by enhanced blood vessel formation in the Chorioallantoic Membrane assay. These findings underscore the formulation's therapeutic potential, marking a significant advance in the use of nanotechnology for topical wound care.

Indexed as

Metal NanoparticlesMicrobial Sensitivity TestsOintmentsSilverWound HealingAcroleinAdministration, TopicalAnimalsAnti-Bacterial AgentsAnti-Infective AgentsCandida albicansHumansPseudomonas aeruginosaStaphylococcus aureusAcroleinAnti-Bacterial AgentsAnti-Infective AgentscinnamaldehydeOintmentsSilverantimicrobial wound ointmentin-vitro antidiabetic activity and wound healing creamphenylpropanoidssilver nanoparticles

Identifiers

PMID38862870

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.