Evidence map›Paper›PMID 38862860›Full record

ArticleMolecular biotechnology2025

Increased Immune Infiltration and Improved Prognosis of Head and Neck Squamous Cell Carcinoma Associated with Reduced Ancient Ubiquitous Protein 1 Gene Expression.

Yi Wang, Qian Wu, Xiao Wei, Gang Huang, Guangyong Feng, Hui Xu, Xiaoxia Gou

Abstract read
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In one paragraph

Article in Molecular biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yi WangDepartment of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.ORCID http://orcid.org/0000-0002-3842-4007
Qian WuDepartment of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Xiao WeiDepartment of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Gang HuangDepartment of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Guangyong FengDepartment of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Hui XuDepartment of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Xiaoxia GouDepartment of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China. gouxx2020@163.com.

Funding

Natural Science Research Project of Guizhou Province ZK-2023-525The Guizhou Anti-Cancer Association Science and Technology Plan Project Anti-Cancer Association ScienceThe Guizhou Anti-Cancer Association Science and Technology Plan Project Technology 006[2023]the Natural Science Foundation of Guizhou Province (Qian Ke He Basic Project ZK [2024]346)The Zunyi Medical University Graduate Student Research Fund (No. ZYK148)
6 · The paper itself

Abstract

This study aimed to explore the molecular mechanism underlying the prognostic role of ancient ubiquitous protein 1 (AUP1) in head and neck squamous cell carcinoma (HNSCC) and its relationship with the tumor immune microenvironment. Various web resources were used to analyze the differential expression of AUP1 and its role in the HNSCC pathogenesis. A nomogram aimed at predicting 1-, 3-, and 5-year survival rates was developed based on the patient's clinicopathological characteristics and AUP1 expression pattern. Several algorithms and analytical tools were used to explore the correlation between AUP1 expression and sensitivity to immune checkpoint gene therapy by evaluating infiltrating immune cells in patients with HNSCC. Higher AUP1 mRNA and protein expression levels were observed in most tumors and HNSCC than in the normal tissues. High AUP1 expression was an independent predictive risk factor for the overall survival of patients as it was closely associated with the patients' T, M, clinical, and pathological stages and lymphovascular invasion in HNSCC. In conclusion, AUP1 is involved in the occurrence and progression of HNSCC, may be used as an independent prognostic factor in patients with HNSCC, and could serve as a potential intervention target to improve immunotherapy sensitivity in HNSCC.

Indexed as

Head and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNomogramsPrognosisTumor MicroenvironmentBiomarkers, TumorAUP1HNSCCImmunotherapy sensitivityPrognostic factors

Identifiers

PMID38862860

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.