Evidence map›Paper›PMID 38862858›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2024

A Common OXTR Risk Variant Alters Regulation of Gene Expression by DNA Hydroxymethylation in Pregnant Human Myometrium.

Joshua S Danoff, Travis S Lillard, Leslie Myatt, Jessica J Connelly, Elise N Erickson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua S DanoffDepartment of Psychology, University of Virginia, Charlottesville, VA, USA.
Travis S LillardDepartment of Psychology, University of Virginia, Charlottesville, VA, USA.
Leslie MyattDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA.
Jessica J Connelly *Department of Psychology, University of Virginia, Charlottesville, VA, USA.
Elise N Erickson *College of Nursing, University of Arizona, Tucson, AZ, USA. eliseerickson@arizona.edu.ORCID 0000-0002-6655-3500

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Luiz Eduardo Bertassoni · 1997 to 2026
$60.5M
Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
Mechanisms of maternal brain changes with birth interventionsR01HD098117 · NICHD · UNIVERSITY OF VIRGINIA · PI JESSICA J CONNELLY, Allison M. Perkeybile · 2019 to 2026
$4.9M
Oxytocin sensitivity and postpartum hemorrhage: testing genetic and epigenetic biomarkers for improving maternal morbidityR01HD111125 · NICHD · UNIVERSITY OF ARIZONA · PI Elise N Erickson · 2023 to 2026
$3.1M
The Clock is Ticking: Epigenetic Age Acceleration as a Biomarker of Uterine Function in PregnancyR00NR019596 · NINR · UNIVERSITY OF ARIZONA · PI ERICKSON, ELISE N · 2022 to 2024
$747k
The Clock is Ticking: Epigenetic Age Acceleration as a Biomarker of Uterine Function in PregnancyK99NR019596 · NINR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ERICKSON, ELISE N · 2020 to 2021
$188k
Eunice Kennedy Shriver National Institute of Child Health and Human Development HD098117Eunice Kennedy Shriver National Institute of Child Health and Human Development K12HD043488Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD111125NCATS NIH HHS UL1 TR002369NCATS NIH HHS UL1TR002369NCI NIH HHS P30 CA069533NICHD NIH HHS K12 HD043488NICHD NIH HHS R01 HD098117NICHD NIH HHS R01 HD111125NINR NIH HHS K99 NR019596NINR NIH HHS K99NR019596NINR NIH HHS R00 NR019596
6 · The paper itself

Abstract

Postpartum hemorrhage, or excessive bleeding after birth, is a leading cause of maternal morbidity. A major cause of postpartum hemorrhage is uterine atony, tiring of the uterus which leads to ineffective contractions. Uterine contractions depend on oxytocin signaling in the myometrium, which in turn depends on expression of the oxytocin receptor (OXTR). Both genetic and epigenetic factors related to the oxytocin receptor are associated with risk of postpartum hemorrhage, but a mechanism relating these factors to oxytocin receptor activity in myometrium remains unclear. We report a genetic by epigenetic interaction whereby the relationship between DNA hydroxymethylation and OXTR gene expression depends on a common OXTR gene variant (rs53576). We also provide evidence that a similar genetic by epigenetic interaction using blood-derived DNA methylation is associated with relevant clinical outcomes: quantity of oxytocin administration and odds for postpartum hemorrhage. These results provide new avenues for predicting how women will respond to pharmacological agents in the prevention and treatment of postpartum hemorrhage.

Indexed as

DNA MethylationEpigenesis, GeneticMyometriumOxytocinPostpartum HemorrhageReceptors, OxytocinAdultFemaleGene Expression RegulationHumansPregnancyOXTR protein, humanOxytocinReceptors, OxytocinDNA hydroxymethylationDNA methylationEpigenetic biomarkerMyometriumOxytocin receptorPostpartum hemorrhage

Identifiers

PMID38862858
PMCPMC11438727

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.