Evidence map›Paper›PMID 38862786›Full record

ArticleNature cell biology2024

The glutathione S-transferase Gstt1 drives survival and dissemination in metastases.

Christina M Ferrer, Hyo Min Cho, Ruben Boon, Tiziano Bernasocchi, Lai Ping Wong, Murat Cetinbas, Elizabeth R Haggerty, Irene Mitsiades, Gregory R Wojtkiewicz, Daniel E McLoughlin and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Christina M FerrerThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. cferrer@som.umaryland.edu.ORCID http://orcid.org/0009-0006-8651-9154
Hyo Min Cho *The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Ruben Boon *The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9355-674X
Tiziano BernasocchiThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7130-5317
Lai Ping WongDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Murat CetinbasDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Elizabeth R HaggertyThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Irene MitsiadesThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9734-6803
Gregory R WojtkiewiczCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3148-8411
Daniel E McLoughlinThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3697-9623
Reem AboushoushaUniversity of Vermont Larner College of Medicine, Burlington, VT, USA.ORCID http://orcid.org/0000-0003-2284-2180
Hend AbdelhamidUniversity of Vermont Larner College of Medicine, Burlington, VT, USA.
Sita KugelFred Hutchison Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7202-187X
Esther RheinbayThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Ruslan SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Dejan JuricThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Yvonne M W Janssen-HeiningerUniversity of Vermont Larner College of Medicine, Burlington, VT, USA.
Raul MostoslavskyThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. rmostoslavsky@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-7740-5212

Funding

Mechanistic Understanding for the Role of Lin28b in Pancreatic Cancer ProgressionR01CA235412 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI EL-BARDEESY, NABEEL, MOSTOSLAVSKY, RAUL · 2019 to 2023
$3.2M
The histone deacetylase SIRT6 modulates Transcriptional pausingR01GM128448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSTOSLAVSKY, RAUL · 2019 to 2022
$1.6M
Role of Gstt1 in metastatic maintenance and self-renewal in PDAR00CA252600 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FERRER, CHRISTINA · 2022 to 2024
$747k
Role of Gstt1 in metastatic maintenance and self-renewal in PDAK99CA252600 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FERRER, CHRISTINA · 2020 to 2021
$313k
NCI NIH HHS K99 CA252600NCI NIH HHS R00 CA252600U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA235412U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM128448
6 · The paper itself

Abstract

Identifying the adaptive mechanisms of metastatic cancer cells remains an elusive question in the treatment of metastatic disease, particularly in pancreatic cancer (pancreatic adenocarcinoma, PDA). A loss-of-function shRNA targeted screen in metastatic-derived cells identified Gstt1, a member of the glutathione S-transferase superfamily, as uniquely required for dissemination and metastasis, but dispensable for primary tumour growth. Gstt1 is expressed in latent disseminated tumour cells (DTCs), is retained within a subpopulation of slow-cycling cells within existing metastases, and its inhibition leads to complete regression of macrometastatic tumours. This distinct Gstt1

Indexed as

Glutathione TransferasePancreatic NeoplasmsTumor MicroenvironmentAdenocarcinomaAnimalsCell Line, TumorCell SurvivalEpithelial-Mesenchymal TransitionFemaleFibronectinsGene Expression Regulation, NeoplasticHumansMiceMice, Inbred C57BLNeoplasm MetastasisFibronectinsglutathione S-transferase T1Glutathione Transferase

Identifiers

PMID38862786

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.