Evidence map›Paper›PMID 38862747›Full record

ArticleCommunications biology2024

Regional brain aging: premature aging of the domain general system predicts aphasia severity.

Natalie Busby, Sarah Newman-Norlund, Sara Sayers, Chris Rorden, Roger Newman-Norlund, Janina Wilmskoetter, Rebecca Roth, Sarah Wilson, Deena Schwen-Blackett, Sigfus Kristinsson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The Influence of Contralesional Brain Age Gradients on Chronic Stroke Aphasia Severity and Treatment Response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Natalie BusbyDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA. hethern@mailbox.sc.edu.ORCID 0000-0001-7117-7899
Sarah Newman-NorlundDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.
Sara SayersDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.
Chris RordenDepartment of Psychology, University of South Carolina, Columbia, SC, USA.
Roger Newman-NorlundDepartment of Psychology, University of South Carolina, Columbia, SC, USA.
Janina WilmskoetterDepartment of Health and Rehabilitation Sciences, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-1083-7301
Rebecca RothDepartment of Neurology, Emory University, Atlanta, GA, USA.
Sarah WilsonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.ORCID 0000-0002-5559-4569
Deena Schwen-BlackettDepartment of Health and Rehabilitation Sciences, Medical University of South Carolina, Charleston, SC, USA.
Sigfus KristinssonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.
Alex TeghipcoDepartment of Psychology, University of South Carolina, Columbia, SC, USA.ORCID 0000-0002-7430-8695
Julius FridrikssonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, USA.
Leonardo BonilhaSchool of Medicine, University of South Carolina, Columbia, SC, USA.

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HICKOK, GREGORY · 2016 to 2025
$25.0M
Cortical and Subcortical Organization of Language-Related Semantic Processing in Alzheimer's DiseaseR01DC014021 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BONILHA, LEONARDO F · 2014 to 2023
$4.7M
Interdisciplinary Research Training in Otolaryngology and Communication SciencesT32DC014435 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUBNO, JUDY R · 2015 to 2024
$2.9M
MOLECULAR BASIS OF MATERNALLY TRANSMITTED DEAFNESSR01DC001402 · NIDCD · CEDARS-SINAI MEDICAL CENTER · PI FISCHEL-GHODSIAN, NATHAN · 1992 to 2005
$1.4M
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC001402NIDCD NIH HHS R01 DC014021NIDCD NIH HHS T32 DC014435U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) T32DC014435
6 · The paper itself

Abstract

Premature brain aging is associated with poorer cognitive reserve and lower resilience to injury. When there are focal brain lesions, brain regions may age at different rates within the same individual. Therefore, we hypothesize that reduced gray matter volume within specific brain systems commonly associated with language recovery may be important for long-term aphasia severity. Here we show that individuals with stroke aphasia have a premature brain aging in intact regions of the lesioned hemisphere. In left domain-general regions, premature brain aging, gray matter volume, lesion volume and age were all significant predictors of aphasia severity. Increased brain age following a stroke is driven by the lesioned hemisphere. The relationship between brain age in left domain-general regions and aphasia severity suggests that degradation is possible to specific brain regions and isolated aging matters for behavior.

Indexed as

AphasiaBrainAdultAgedAgingAging, PrematureFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedSeverity of Illness IndexStroke

Identifiers

PMID38862747
PMCPMC11167062

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.