Evidence map›Paper›PMID 38862726›Full record

ArticleNeurochemical research2024

Idebenone Antagonizes P53-Mediated Neuronal Oxidative Stress Injury by Regulating CD38-SIRT3 Protein Level.

Hao Xu, Ying Guo, Xiao-Jun Liu, Ying Liu, Shi Yin, Qi-Ying Bao, Ru Peng, Wei-Bo Tian, Ying-Yan Xia, Ling Gao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hao Xu *Department of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, P.R. China.
Ying Guo *Department of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, P.R. China.
Xiao-Jun Liu *China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, China.
Ying LiuDepartment of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, P.R. China.
Shi YinDepartment of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, P.R. China.
Qi-Ying BaoDepartment of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, P.R. China.
Ru PengJiangsu Health Vocational College, Nanjing, P.R. China.
Wei-Bo TianJilin University, Changchun, P.R. China.
Ying-Yan XiaBethune Second Clinical School of Medicine, Jilin University, Changchun, P.R. China.
Ling GaoBasic medical department of Changchun Medical College, Changchun, P.R. China. 348967945@qq.com.
Jia-Mei LiuDepartment of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, P.R. China. liujm@jlu.edu.cn.

Funding

Science and technology research project from Education Department of Jilin Province JJKH20221348KJ
6 · The paper itself

Abstract

Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD38) and Silent message regulator 3 (SIRT3) protein expression and possibly impacting SIRT3's ability to deacetylate Tumor protein p53 (P53). This study explores the relationship between CD38, SIRT3, and P53 in H

Indexed as

ADP-ribosyl Cyclase 1ApoptosisOxidative StressSirtuin 3Tumor Suppressor Protein p53UbiquinoneAnimalsAntioxidantsCell LineHydrogen PeroxideMembrane GlycoproteinsMiceNeuronsNeuroprotective AgentsADP-ribosyl Cyclase 1AntioxidantsCd38 protein, mouseHydrogen PeroxideidebenoneMembrane GlycoproteinsNeuroprotective AgentsSirt3 protein, mouseSirtuin 3Trp53 protein, mouseTumor Suppressor Protein p53UbiquinoneCD38DeacetylationH2O2IdebenoneP53SIRT3

Identifiers

PMID38862726
PMCPMC11310240

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.