Evidence map›Paper›PMID 38862663›Full record

SynthesisAAPS PharmSciTech2024

QbD Assisted Systematic Review for Optimizing the Selection of PVP as a Ternary Substance in Enhancing the Complexation Efficiency of Cyclodextrins: a Pilot Study.

Glovanna Mulenga, Teejan Ameer Abed Alahmed, Farheen Sami, Shahnaz Majeed, Md Sajid Ali, Janice Lo Jia Le, Carol Lee Qhai Rhu, Rajesh Sreedharan Nair, Nadeem Hasan, Mohammed Tahir Ansari

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in AAPS PharmSciTech, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Glovanna Mulenga *School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Teejan Ameer Abed Alahmed *School of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia.
Farheen SamiSchool of Pharmaceutical Sciences, CT University, Ferozepur Road, Sidhwan Khurd, 142024, India.
Shahnaz MajeedDepartment of Basic Science, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, 30450, Ipoh, Malaysia.
Md Sajid AliDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia.
Janice Lo Jia LeSchool of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia.
Carol Lee Qhai RhuSchool of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia.
Rajesh Sreedharan NairSchool of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia.
Nadeem HasanDepartment of Pharmaceutics, MAM College of Pharmacy, P&T Colony, Kalaburgi, 585102, India.
Mohammed Tahir Ansari *School of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia. Tahir.Ansari@nottingham.edu.my.ORCID http://orcid.org/0000-0001-5834-7726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inclusion complexes require higher concentration of Beta cyclodextrins (βCD) resulting in increased formulation bulk, toxicity, and production costs. This systematic review offers a comprehensive analysis using Quality by design (QbD) as a tool to predict potential applications of Polyvinylpyrrolidone (PVP) as a ternary substance to address issues of inclusion complexes. We reviewed 623 documents from 2013 to 2023 and Eighteen (18) research papers were selected for statistical and meta-analysis using the QbD concept to identify the most critical factors for selecting drugs and effect of PVP on inclusion complexes. The QbD analysis revealed that Molecular weight (MW), Partition coefficient (Log P), and the auxiliary substance ratio directly affected complexation efficiency (CE), thermodynamic stability in terms of Gibbs free energy (ΔG), and percent drug release. However, Stability constant (K

Indexed as

beta-CyclodextrinsCyclodextrinsPovidoneSolubilityChemistry, PharmaceuticalDrug LiberationExcipientsMolecular WeightPilot ProjectsThermodynamicsbeta-CyclodextrinsCyclodextrinsExcipientsPovidonebeta cyclodextrins (βCD)box behnken designlog Ppolyvinylpyrrolidone (PVP)quality by design (QbD)ternary substance

Identifiers

PMID38862663

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.