Evidence map›Paper›PMID 38862654›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Impaired gut barrier integrity and reduced colonic expression of free fatty acid receptors in patients with Parkinson's disease.

Peng-Hsiang Liao, Hsiao-Yen Tung, Wee Shin Lim, Jyh-Shing Roger Jang, Hsun Li, Chia-Tung Shun, Han-Mo Chiu, Ming-Shiang Wu, Chin-Hsien Lin

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Beyond bacteria: a multi-omics view of the gut-brain axis in Parkinson's disease.Frontiers in cellular and infection microbiology · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng-Hsiang LiaoCollege of Medicine, National Taiwan University, Taipei, Taiwan.
Hsiao-Yen TungCollege of Medicine, National Taiwan University, Taipei, Taiwan.
Wee Shin LimDepartment of Computer Science & Information Engineering, National Taiwan University, Taipei, Taiwan.
Jyh-Shing Roger JangDepartment of Computer Science & Information Engineering, National Taiwan University, Taipei, Taiwan.
Hsun LiDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Chia-Tung ShunDepartment of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Han-Mo ChiuDepartment of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chin-Hsien LinCollege of Medicine, National Taiwan University, Taipei, Taiwan. chlin@ntu.edu.tw.ORCID http://orcid.org/0000-0001-8566-7573

Funding

National Research Health Institutes NHRI-EX113-11136NINational Science and Technology Council 112-2321-B-002 -023National Taiwan University NTU-110-A-CC-5400-64841National Taiwan University Hospital 113-E0004
6 · The paper itself

Abstract

backgroundAltered gut metabolites, especially short-chain fatty acids (SCFAs), in feces and plasma are observed in patients with Parkinson's disease (PD).

objectiveWe aimed to investigate the colonic expression of two SCFA receptors, free fatty acid receptor (FFAR)2 and FFAR3, and gut barrier integrity in patients with PD and correlations with clinical severity.

methodsIn this retrospective study, colonic biopsy specimens were collected from 37 PD patients and 34 unaffected controls. Of this cohort, 31 participants (14 PD, 17 controls) underwent a series of colon biopsies. Colonic expression of FFAR2, FFAR3, and the tight junction marker ZO-1 were assayed by immunofluorescence staining. The You Only Look Once (version 8, YOLOv8) algorithm was used for automated detection and segmentation of immunostaining signal. PD motor function was assessed with the Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (UPDRS), and constipation was assessed using Rome-IV criteria.

resultsCompared with controls, PD patients had significantly lower colonic expression of ZO-1 (p < 0.01) and FFAR2 (p = 0.01). On serial biopsy, colonic expression of FFAR2 and FFAR3 was reduced in the pre-motor stage before PD diagnosis (both p < 0.01). MDS-UPDRS motor scores did not correlate with colonic marker levels. Constipation severity negatively correlated with colonic ZO-1 levels (r = -0.49, p = 0.02).

conclusionsColonic expression of ZO-1 and FFAR2 is lower in PD patients compared with unaffected controls, and FFAR2 and FFAR3 levels decline in the pre-motor stage of PD. Our findings implicate a leaky gut phenomenon in PD and reinforce that gut metabolites may contribute to the process of PD.

Indexed as

ColonParkinson DiseaseReceptors, G-Protein-CoupledAgedConstipationFemaleHumansMaleMiddle AgedRetrospective StudiesZonula Occludens-1 ProteinFFAR2 protein, humanFFAR3 protein, humanReceptors, G-Protein-CoupledTJP1 protein, humanZonula Occludens-1 ProteinFree fatty acid receptorLeaky gutParkinson’s diseaseShort-chain fatty acidTight junction

Identifiers

PMID38862654

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.