ArticleNature communications2024
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
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Who cites it
54 citing papers in PubMed.
- Article
- Human induced pluripotent stem cells and organoid models in space for investigating severe pediatric metabolic and congenital disorders.Precision clinical medicine · 2026Review
- Impact of Microgravity on Cytoskeletal Dynamics, Protein Transport, and Signaling Networks: Potential Therapeutic Opportunities for Skin Health.International journal of molecular sciences · 2026Review
- The transgenerational toll of maternal spaceflight.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Long-term major histocompatibility complex class I suppression in astronauts and clinical implications.Communications biology · 2026Review
- Suborbital spaceflight reveals rapid changes in gene expression accompanying the transition to and from space.NPJ microgravity · 2026Article
- Spaceflight multi-omics reveals vulnerabilities of human germ cell development.Science advances · 2026Article
- Space radiation and microgravity as models of accelerated aging: modulation of hepatic miRNA-TGF-β networks associated with senescence and fibrosis.GeroScience · 2026Article
- Effects of the space environment on articular cartilage homeostasis: a review.NPJ microgravity · 2026Review
- Multi-Omics Characterization of Human Molecular Responses to Spaceflight Across Two Independent Missions.bioRxiv : the preprint server for biology · 2026Article
- Multiomics analysis of the molecular and single-cell responses of rice after deep-space flight on Chang'e-5.Nature communications · 2026Article
- MAPK/PMK-1 innate immune signaling protects the nematode Caenorhabditis elegans from increased intestinal colonization in an animal host-pathogen model in space.NPJ microgravity · 2026Article
- Understanding Spaceflight-Induced Oxidative Stress and the Critical Role of Diet and Microbiome.Antioxidants (Basel, Switzerland) · 2026Review
- Simulated Microgravity Recapitulates Aspects of Biological Aging in Humans.bioRxiv : the preprint server for biology · 2026Article
- Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.Nature reviews. Immunology · 2026Review
- Biofilms: from the cradle of life to life support.NPJ biofilms and microbiomes · 2026Review
- Spaceflight alters the immune regulatory functions of neutrophil granulocytes on T lymphocytes.iScience · 2026Article
- Spaceflight alters molecular networks linked to diverse human diseases in a single cellular model.Science advances · 2026Article
- Precision Medicine in Astronauts: Principles and Targets in Molecular Assessment.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Systemic elevation of gut derivedFrontiers in physiology · 2026Article
Corrections and comments
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Authors and funding
50 authors.
JangKeun Kim *Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.ORCID 0000-0002-8733-9925
Braden T Tierney *Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.ORCID 0000-0002-7533-8802
Eliah G OverbeyDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.ORCID 0000-0002-2866-8294
Ezequiel DantasDivision of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.ORCID 0000-0003-4934-4632
Matias FuentealbaBuck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Jiwoon ParkDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.ORCID 0000-0003-0045-1429
S Anand NarayananDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
Fei WuBuck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, 94945, USA.ORCID 0000-0002-8353-7676
Deena NajjarDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.ORCID 0009-0009-7950-2866
Christopher R ChinThe HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA.ORCID 0000-0002-2140-3197
Cem MeydanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.ORCID 0000-0002-0663-6216
Conor LoyCornell University, Meinig School of Biomedical Engineering, Ithaca, NY, 14850, USA.
Begum MathykDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of South Florida Morsani College of Medicine, Tampa, FL, USA.ORCID 0000-0001-9832-6284
Remi KlotzDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-2100-0635
Veronica OrtizDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Khiem NguyenBuck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Krista A RyonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.
Namita DamleDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.
Nadia HouerbiDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.
Laura I PatrasChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Nathan SchanzerSchool of Medicine, New York Medical College, Valhalla, NY, 10595, USA.
Gwyneth A HutchinsonNASA Center for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, 94720, USA.ORCID 0000-0001-9706-0461
Jonathan FooxDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.
Chandrima BhattacharyaThe HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, 10021, USA.
Matthew MackayTri-Institutional Biology and Medicine Program, Weill Cornell Medicine, New York, NY, 10021, USA.
Evan E AfshinDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.
Jeremy Wain HirschbergDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.
Ashley S KleinmanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA.
Julian C SchmidtSovaris Aerospace, Boulder, CO, USA.
Caleb M SchmidtSovaris Aerospace, Boulder, CO, USA.
Michael A SchmidtSovaris Aerospace, Boulder, CO, USA.
Afshin BeheshtiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.ORCID 0000-0003-4643-531X
Irina MateiMeyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.ORCID 0000-0002-5712-8430
David LydenMeyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.ORCID 0000-0003-0193-4131
Sean MullaneSpace Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.
Amran AsadiSpace Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.
Joan S LenzCornell University, Meinig School of Biomedical Engineering, Ithaca, NY, 14850, USA.
Omary MzavaCornell University, Meinig School of Biomedical Engineering, Ithaca, NY, 14850, USA.
Min YuDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Saravanan GanesanMeyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.
Iwijn De VlaminckCornell University, Meinig School of Biomedical Engineering, Ithaca, NY, 14850, USA.ORCID 0000-0001-6085-7311
Ari M MelnickMeyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.ORCID 0000-0002-8074-2287
Darko BarisicMeyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.ORCID 0000-0001-7007-9138
Daniel A WinerBuck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, 94945, USA.ORCID 0000-0002-8702-0957
Sara R ZwartUniversity of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.ORCID 0000-0001-8694-0180
Brian E CrucianBiomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Human Health and Performance Directorate, 2101 NASA Parkway, Houston, TX, 77058, USA.
Scott M SmithBiomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Human Health and Performance Directorate, 2101 NASA Parkway, Houston, TX, 77058, USA.ORCID 0000-0001-9313-7900
Jaime MateusBlue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, USA.
David FurmanBuck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, 94945, USA. dfurman@buckinstitute.org.ORCID 0000-0002-3654-9519
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 100221, USA. chm2042@med.cornell.edu.ORCID 0000-0002-1850-1642
Funding
Project 3: Targeting PRMT5 in Mantle Cell LymphomaP01CA214274 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PAIK, JIHYE · 2018 to 2022
$8.9MTargeting Epigenetic Circuits in B-Cell LymphomasR35CA220499 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MELNICK, ARI M. · 2018 to 2024
$7.2MClinical and Molecular Heterogeneity in the Myelodysplastic SyndromesR01CA249054 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MASON, CHRISTOPHER EDWARD, PARK, CHRISTOPHER Y · 2020 to 2024
$3.5MMetagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantationR01AI151059 · NIAID · CORNELL UNIVERSITY · PI DADHANIA, DARSHANA, DE VLAMINCK, IWIJN · 2020 to 2024
$3.4MThe Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3MRole of Chromatin Remodeling Complex BAF in Immunity and LymphomaK99CA246080 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BARISIC, DARKO · 2020 to 2022
$381kNASA | Johnson Space Center (JSC) 80NSSC22K0254NASA | Johnson Space Center (JSC) NNH18ZTT001N-FG2NASA | Johnson Space Center (JSC) NNX17AB26GNCI NIH HHS K99 CA246080NCI NIH HHS P01 CA214274NCI NIH HHS R01 CA249054NCI NIH HHS R35 CA220499NIAID NIH HHS R01 AI151059NIMH NIH HHS R01 MH117406
Abstract
Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found that 18 cytokines/chemokines related to inflammation, aging, and muscle homeostasis changed after spaceflight. In I4 single-cell multi-omics data, we identified a "spaceflight signature" of gene expression characterized by enrichment in oxidative phosphorylation, UV response, immune function, and TCF21 pathways. We confirmed the presence of this signature in independent datasets, including the NASA Twins Study, the I4 skin spatial transcriptomics, and 817 NASA GeneLab mouse transcriptomes. Finally, we observed that (1) T cells showed an up-regulation of FOXP3, (2) MHC class I genes exhibited long-term suppression, and (3) infection-related immune pathways were associated with microbiome shifts. In summary, this study reveals conserved and distinct immune disruptions occurring and details a roadmap for potential countermeasures to preserve astronaut health.
Indexed as
Single-Cell AnalysisSpace FlightTranscriptomeAnimalsAstronautsCytokinesFemaleGene Expression ProfilingHumansMaleMiceOxidative PhosphorylationSex FactorsT-LymphocytesCytokines
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