ArticleScientific reports2024
Trends and age-period-cohort effect on incidence of hepatitis B from 2008 to 2022 in Guangzhou, China.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Multiple Aflatoxins Drive Cumulative Dietary Exposure and Hepatocellular Carcinoma Risk: An Age-Stratified Study in Guangzhou, China.Foods (Basel, Switzerland) · 2026Article
- Trends and forecasting of reported hepatitis B and hepatitis C incidence in Hainan Province, China, 2005-2020.Frontiers in epidemiology · 2026Article
- Age-period-cohort analysis of pulmonary tuberculosis epidemiological trends from 2005 to 2024 and forecasts for 2035 in Sichuan Province, China.Frontiers in public health · 2026Article
- Epidemic Trends and Spatial Distribution Characteristics of Hepatitis B in China: Surveillance Study.JMIR public health and surveillance · 2025Article
- Hepatitis B Hospitalizations in Brazil: Temporal and Regional Patterns from 2008 to 2023.Viruses · 2025Article
- Epidemiological trends and projections to 2035 of hepatitis B burden in China, 1990-2021.PloS one · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Hepatitis B virus (HBV) infection is highly prevalent in Guangzhou, China. This study aimed to examine the long-term trend of HB incidence from 2008 to 2022 and the independent impacts of age, period, and cohort on the trends. HBV data were collected from the China Information System for Disease Control and Prevention. Joinpoint regression was utilized to examine temporal trends, and an age-period-cohort model was employed to estimate the effects of age, period, and cohort. A total of 327,585 HBV cases were included in this study. The incidence of chronic and acute HB showed a decreasing trend in Guangzhou over the past 15 years, with an average annual percent change of - 4.31% and - 16.87%, respectively. Age, period, and cohort all exerted significant effects. The incidence of HB was higher in males than in females and non-central areas compared to central areas. Age groups of 0-4 years and 15-24 years were identified as high-risk groups. The period relative risks for chronic HB incidence decreased initially and then stabilized. Cohorts born later had lower risks. Chronic HB incidences remain high in Guangzhou, especially among males, younger individuals, and residents of non-central areas. More efforts are still needed to achieve hepatitis elimination targets.
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