Evidence map›Paper›PMID 38862484›Full record

ArticleNature communications2024

Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction.

Keith Siew, Kevin A Nestler, Charlotte Nelson, Viola D'Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R Wan, Vaksha Patel, Eliah Overbey and 95 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. The Final Frontier: Toward Transformative Insights into the Pathophysiologic Adaptations to Microgravity with Molecular Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. Biofilms: from the cradle of life to life support.NPJ biofilms and microbiomes · 2026
    Review
  7. Article
  8. Article
  9. Systemic elevation of gut derivedFrontiers in physiology · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

105 authors.

Keith SiewLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK. k.siew@ucl.ac.uk.ORCID 0000-0002-6502-5095
Kevin A NestlerThe Institute for Biomedical Sciences (IBS), The George Washington University, Washington, DC, USA.
Charlotte NelsonWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3687-1102
Viola D'AmbrosioLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK.
Chutong ZhongLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK.
Zhongwang LiLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK.
Alessandra GrilloLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK.ORCID 0000-0001-6482-8796
Elizabeth R WanLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK.
Vaksha PatelDepartment of Renal Medicine, University College London, London, UK.
Eliah OverbeyInstitute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-2866-8294
JangKeun KimInstitute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-8733-9925
Sanghee YunUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0001-7505-0836
Michael B VaughanSchool of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.ORCID 0000-0002-9979-1265
Chris CheshireBioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK.
Laura CubittApplied Biotechnology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0003-1948-6795
Jessica Broni-TabiSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Maneera Yousef Al-JaberAnti-Doping Laboratory Qatar, Doha, Qatar.ORCID 0000-0002-5051-7345
Valery BoykoSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0002-3724-9294
Cem MeydanInstitute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-0663-6216
Peter BarkerMRC MDU Mouse Biochemistry Laboratory, University of Cambridge, Cambridge, UK.
Shehbeel ArifCenter for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Fatemeh AfsariDepartment of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA.
Noah AllenDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.ORCID 0000-0003-0998-8337
Mohammed Al-MaadheedAnti-Doping Laboratory Qatar, Doha, Qatar.
Selin AltinokSchool of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nourdine BahApplied Biotechnology Laboratory, The Francis Crick Institute, London, UK.
Samuel BorderDepartment of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA.
Amanda L BrownPharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Keith BurlingMRC MDU Mouse Biochemistry Laboratory, University of Cambridge, Cambridge, UK.
Margareth Cheng-CampbellDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Lorianna M ColónDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Lovorka DegoricijaKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Nichola FiggDepartment of Medicine, University of Cambridge, Cambridge, UK.
Rebecca FinchSchool of Health, Science and Wellbeing, Staffordshire University, Stoke-on-Trent, UK.
Jonathan FooxDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.
Pouya FaridiMonash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Alison FrenchSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Samrawit GebreSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Peter GordonSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Nadia HouerbiPhysiology, Biophysics & Systems Biology, Weill Cornell Medical College, New York, NY, USA.
Hossein Valipour KahroodMonash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-4166-0382
Frederico C KifferDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-5269-3951
Aleksandra S KlosinskaDivision of Experimental Medicine & Immunotherapeutics (EMIT), Department of Medicine, University of Cambridge, Cambridge, UK.
Angela KubikDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Han-Chung LeeMonash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Yinghui LiState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.ORCID 0000-0002-9294-4652
Nicholas LucarelliDepartment of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA.
Anthony L MarulloSchool of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.ORCID 0000-0002-1460-7167
Irina MateiCornell Center for Immunology, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-5712-8430
Colleen M McCannPharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sayat MimarDepartment of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA.
Ahmed NaglahDepartment of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA.
Jérôme NicodAdvanced Sequencing Facility, The Francis Crick Institute, London, UK.ORCID 0000-0003-2459-3480
Kevin M O'ShaughnessyDivision of Experimental Medicine & Immunotherapeutics (EMIT), Department of Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1476-7566
Lorraine Christine De OliveiraBlue Marble Space Institute of Science, Seattle, WA, USA.
Leah OswaltPharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-7097-0801
Laura Ioana PatrasPediatrics, Weill Cornell Medical College, New York, NY, USA.
San-Huei Lai PoloKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0003-1460-6647
María Rodríguez-LopezAdvanced Sequencing Facility, The Francis Crick Institute, London, UK.ORCID 0000-0002-2066-0589
Candice RoufosseDepartment of Immunology and Inflammation, Imperial College London, London, UK.ORCID 0000-0002-6490-4290
Omid Sadeghi-AlavijehDepartment of Renal Medicine, University College London, London, UK.
Rebekah Sanchez-HodgePharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anindya S PaulDepartment of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA.
Ralf Bernd SchittenhelmMonash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-8738-1878
Annalise SchweickartInstitute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0001-9691-3741
Ryan T ScottKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0003-0654-5661
Terry Chin Choy Lim Kam SianMonash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-7038-1214
Willian A da SilveiraSchool of Health, Science and Wellbeing, Staffordshire University, Stoke-on-Trent, UK.
Hubert SlawinskiAdvanced Sequencing Facility, The Francis Crick Institute, London, UK.ORCID 0000-0002-8996-8477
Daniel SnellAdvanced Sequencing Facility, The Francis Crick Institute, London, UK.ORCID 0000-0002-0105-8437
Julio SosaUniversity Health Network, Toronto, ON, Canada.ORCID 0000-0001-5516-5724
Amanda M Saravia-ButlerKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Marshall TabetahDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-1651-7659
Erwin TanuwidjayaMonash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Simon Walker-SamuelCentre for Advanced Biomedical Imaging, University College London, London, UK.ORCID 0000-0003-3530-9166
Xiaoping YangProteomics, King's College London, London, UK.
YasminDivision of Experimental Medicine & Immunotherapeutics (EMIT), Department of Medicine, University of Cambridge, Cambridge, UK.
Haijian ZhangMonash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Jasminka Godovac-ZimmermannDepartment of Renal Medicine, University College London, London, UK.ORCID 0000-0002-6820-4128
Pinaki SarderDepartment of Medicine-Quantitative Health Section, University of Florida, Gainesville, FL, USA.
Lauren M SandersSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0001-9393-0861
Sylvain V CostesSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0002-8542-2389
Robert A A CampbellSainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Fathi KarouiaBlue Marble Space Institute of Science, Seattle, WA, USA.ORCID 0000-0002-1142-9684
Vidya Mohamed-AlisAnti-Doping Laboratory Qatar, Doha, Qatar.
Samuel RodriquesApplied Biotechnology Laboratory, The Francis Crick Institute, London, UK.
Steven LynhamProteomics, King's College London, London, UK.
Joel Ricky SteeleMonash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-3070-9761
Sergio BaranziniWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0067-194X
Hossein FazeliniaDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Zhongquan DaiState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Akira UrunoDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.ORCID 0000-0002-9224-0161
Dai ShibaMouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki, Japan.ORCID 0000-0003-3808-5428
Masayuki YamamotoDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
Eduardo A C AlmeidaSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Elizabeth BlaberDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Jonathan C SchislerPharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-7382-2783
Amelia J EischDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-6476-5385
Masafumi MurataniInstitute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID 0000-0002-0276-8000
Sara R ZwartDepartment of Preventative Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0001-8694-0180
Scott M SmithNASA Johnson Space Center, Houston, TX, USA.ORCID 0000-0001-9313-7900
Jonathan M GalazkaSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0002-4153-0249
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-1850-1642
Afshin BeheshtiKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0003-4643-531X
Stephen B WalshLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK. stephen.walsh@ucl.ac.uk.ORCID 0000-0002-8693-1353

Funding

Training Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9M
Computational Imaging of Renal Structures for Diagnosing DiabeticNephropathyR01DK114485 · NIDDK · UNIVERSITY OF FLORIDA · PI Michael Thomas Eadon, Avi Z Rosenberg · 2018 to 2026
$4.7M
The Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3M
Dual CHIP Functions Control Tau Triage In Alzheimer's DiseaseR01AG061188 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, TODD JONATHAN, SCHISLER, JONATHAN C. · 2019 to 2023
$3.1M
EVIDARA: Automated Evidential Support from Raw Data for relay agents in Biomedical KG QueriesOT2TR003450 · NCATS · INSTITUTE FOR SYSTEMS BIOLOGY · PI BARANZINI, SERGIO E, HUANG, SUI · 2020 to 2024
$2.9M
B Cells Directly Alter Adaptive Plasticity to Support Functional Recovery After StrokeR01NS088555 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI STOWE, ANN MARIE · 2015 to 2025
$2.8M
Computational Image Analysis of Renal Transplant Biopsies to Predict Graft OutcomeR01DK129541 · NIDDK · UNIVERSITY OF FLORIDA · PI Kuang-Yu Jen, Pinaki Sarder · 2023 to 2026
$2.8M
Protein quality control in age-related diseasesR01AG066710 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHISLER, JONATHAN C. · 2020 to 2024
$2.4M
Basic Science Training Program in the Neurobiology of Mental IllnessT32MH076690 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2017
$2.3M
Early life bladder inflammatory events in female mice lead to subsequent LUTS in adulthoodR01DK135871 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Stephen Anthony Zderic · 2023 to 2026
$2.3M
Behavioral pattern separation: orchestration by lateral entorhinal cortex-hippocampal circuitryR01MH129970 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI EISCH, AMELIA J · 2023 to 2025
$2.1M
Network modulation to improve gene therapy in CLN3 diseaseR01NS126279 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Rebecca Clare Ahrens-Nicklas · 2023 to 2026
$2.0M
British Heart Foundation PG/20/10270NCATS NIH HHS OT2 TR003450NIAMS NIH HHS R01 AR080668NIA NIH HHS R01 AG061188NIA NIH HHS R01 AG066710NIDDK NIH HHS R01 DK114485NIDDK NIH HHS R01 DK129541NIDDK NIH HHS R01 DK135871NIMH NIH HHS R01 MH117406NIMH NIH HHS R01 MH129970NIMH NIH HHS R15 MH117628NIMH NIH HHS T32 MH076690NINDS NIH HHS R01 NS088555NINDS NIH HHS R01 NS126279NINDS NIH HHS T32 NS007413UK Space Agency (United Kingdom Space Agency) ST/X000036/1Wellcome Trust CC2168
6 · The paper itself

Abstract

Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts' increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.

Indexed as

Cosmic RadiationSpace FlightAnimalsAstronautsFemaleHumansKidneyKidney DiseasesMaleMarsMiceMice, Inbred C57BLProteomicsRatsWeightlessnessWeightlessness Simulation

Identifiers

PMID38862484
PMCPMC11167060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.