Evidence map›Paper›PMID 38862476›Full record

ArticleNature communications2024

Transcranial focused ultrasound to V5 enhances human visual motion brain-computer interface by modulating feature-based attention.

Joshua Kosnoff, Kai Yu, Chang Liu, Bin He

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Brain-computer interface-based neurofeedback training enables transferable control of cortical state switching in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Transcranial Focused Ultrasound Enhances the Discriminative Power of Targeted Voluntary Motor Signals in Humans.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
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  18. Non-Invasive Brain-Computer Interfaces: State of the Art and Trends.IEEE reviews in biomedical engineering · 2025
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Joshua KosnoffDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15237, USA.ORCID http://orcid.org/0000-0003-3799-4216
Kai YuDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15237, USA.ORCID http://orcid.org/0000-0002-4778-4389
Chang LiuDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15237, USA.ORCID http://orcid.org/0000-0001-5560-7203
Bin HeDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15237, USA. bhe1@andrew.cmu.edu.ORCID http://orcid.org/0000-0003-2944-8602

Funding

Electrophysiological Source Imaging of Partial EpilepsyR01NS096761 · NINDS · UNIVERSITY OF MINNESOTA · PI HE, BIN · 2016 to 2025
$3.6M
Electrophysiology-Compatible Wearable Transcranial Focused Ultrasound Neuromodulation Array ProbesRF1NS131069 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI HE, BIN · 2023 to 2023
$3.6M
Imaging Epilepsy Sources with Biophysically Constrained Deep Neural NetworksR01NS127849 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI BIN HE · 2023 to 2026
$2.4M
Treating pain in sickle cell disease by means of focused ultrasound neuromodulationU18EB029354 · NIBIB · CARNEGIE-MELLON UNIVERSITY · PI HE, BIN · 2019 to 2019
$2.0M
Characterization of in vivo neuronal and inter-neuronal responses to transcranial focused ultrasoundR01NS124564 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI HE, BIN · 2021 to 2021
$2.0M
Mind-body awareness training and brain-computer interfaceR01AT009263 · NCCIH · UNIVERSITY OF MINNESOTA · PI HE, BIN · 2016 to 2020
$2.0M
Integrative Training in Neural InterfacingT32EB029365 · NIBIB · CARNEGIE-MELLON UNIVERSITY · PI HE, BIN · 2021 to 2025
$1.0M
National Science Foundation (NSF) DGE2140739NCCIH NIH HHS R01 AT009263NIBIB NIH HHS T32 EB029365NIBIB NIH HHS U18 EB029354NINDS NIH HHS R01 NS096761NINDS NIH HHS R01 NS124564NINDS NIH HHS R01 NS127849NINDS NIH HHS RF1 NS131069U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health (NCCIH) R01AT009263U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) T32EB029365U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) U18EB029354, T32EB029365U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS124564, RF1NS131069, R01NS096761, and NS127849
6 · The paper itself

Abstract

A brain-computer interface (BCI) enables users to control devices with their minds. Despite advancements, non-invasive BCIs still exhibit high error rates, prompting investigation into the potential reduction through concurrent targeted neuromodulation. Transcranial focused ultrasound (tFUS) is an emerging non-invasive neuromodulation technology with high spatiotemporal precision. This study examines whether tFUS neuromodulation can improve BCI outcomes, and explores the underlying mechanism of action using high-density electroencephalography (EEG) source imaging (ESI). As a result, V5-targeted tFUS significantly reduced the error in a BCI speller task. Source analyses revealed a significantly increase in theta and alpha activities in the tFUS condition at both V5 and downstream in the dorsal visual processing pathway. Correlation analysis indicated that the connection within the dorsal processing pathway was preserved during tFUS stimulation, while the ventral connection was weakened. These findings suggest that V5-targeted tFUS enhances feature-based attention to visual motion.

Indexed as

AttentionBrain-Computer InterfacesElectroencephalographyAdultFemaleHumansMaleMotion PerceptionPhotic StimulationVisual CortexYoung Adult

Identifiers

PMID38862476
PMCPMC11167030

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.