ArticleNature communications2024
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biological clocks and blood clots in space: circadian disruption-induced modulation of thrombosis risk.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Impact of Microgravity on Cytoskeletal Dynamics, Protein Transport, and Signaling Networks: Potential Therapeutic Opportunities for Skin Health.International journal of molecular sciences · 2026Review
- Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.Immunity · 2026Article
- Male reproductive biology was reshaped during placental mammal diversification through epididymal secretome expansion.EMBO reports · 2026Article
- Multi-Omics Characterization of Human Molecular Responses to Spaceflight Across Two Independent Missions.bioRxiv : the preprint server for biology · 2026Article
- Review
- Understanding Spaceflight-Induced Oxidative Stress and the Critical Role of Diet and Microbiome.Antioxidants (Basel, Switzerland) · 2026Review
- Simulated spaceflight disrupts the immune-gut-brain axis and drives sex-dependent neuroinflammation, axonal injury, and behavioral deficits.bioRxiv : the preprint server for biology · 2026Article
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- Extraterrestrial regolith is hemostatic and potentially suitable for hemorrhage control in space.Research and practice in thrombosis and haemostasis · 2026Article
- Proteograph™-based proteome and sphingolipidome analyses identified novel serum biomarkers to monitor astronauts' health in spaceflight.Frontiers in physiology · 2026Article
- Simulated Microgravity-Induced Changes in SUMOylation and Protein Expression inInternational journal of molecular sciences · 2025Article
- A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: lessons from human and animal studies.NPJ microgravity · 2025Article
- Children's health: insights from space medicine on metabolic health.NPJ microgravity · 2025Review
- Multiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics.Journal of proteome research · 2025Article
- Pharmaceutical and biomedical challenges for crew autonomy in health preservation during future exploration missions.Communications medicine · 2025Review
- Multi-Omics Profiling of Individuals Sustaining Extreme Physical Stressors.Life (Basel, Switzerland) · 2025Review
- Dynamic Changes in Hindlimb Motor Cortex Neurons during Simulated Weightlessness Revealed by Miniature 2-Photon Microscopy.Research (Washington, D.C.) · 2025Article
- Article
- Review
Corrections and comments
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Authors and funding
39 authors.
Funding
Abstract
As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated "spaceflight secretome profiles," which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins. While >93% of differentially abundant proteins (DAPs) in vesicles and metabolites recovered within six months, the majority (73%) of plasma DAPs were still perturbed post-flight. Moreover, these proteomic alterations correlated better with peripheral blood mononuclear cells than whole blood, suggesting that immune cells contribute more DAPs than erythrocytes. Finally, to discern possible mechanisms leading to brain-enriched protein detection and blood-brain barrier (BBB) disruption, we examined protein changes in dissected brains of spaceflight mice, which showed increases in PECAM-1, a marker of BBB integrity. These data highlight how even short-duration spaceflight can disrupt human and murine physiology and identify spaceflight biomarkers that can guide countermeasure development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.