Evidence map›Paper›PMID 38862457›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Bioinformatic analysis of CCND2 expression in papillary thyroid carcinoma and its impact on immune infiltration].

Q Wang, B Song, S Hao, Z Xiao, L Jin, T Zheng, F Chai

Abstract readEnglish Abstract
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Q WangDepartment of Thyroid Surgery, First Affiliated Hospital, Jinzhou Medical University, Jinzhou 121001, China.
B SongDepartment of Endocrinology and Metabolic Diseases, First Affiliated Hospital, Jinzhou Medical University, Jinzhou 121001, China.
S HaoDepartment of anesthesiology, First Affiliated Hospital, Jinzhou Medical University, Jinzhou 121001, China.
Z XiaoHengshui People's Hospital, Hengshui 053000, China.
L JinYingkou People's Hospital, Yingkou 115000, China.
T ZhengDepartment of Thyroid Surgery, First Affiliated Hospital, Jinzhou Medical University, Jinzhou 121001, China.
F ChaiDepartment of Thyroid Surgery, First Affiliated Hospital, Jinzhou Medical University, Jinzhou 121001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate cyclin D2 (CCND2) expression in papillary thyroid carcinoma (PTC) and its association with the clinicopathological features.

methodsThe public databases TCGA, TIMER 2.0 and UALCAN were used to explore CCND2 expression level in PTC and adjacent tissues, and its diagnostic value for PTC was analyzed using ROC curves. GO enrichment analysis of CCND2-related differentially expressed genes (DEGs) in PTC was performed, and tumor immune infiltration of CCND2 in thyroid cancer was analyzed using TIMER database and CIBERSORT data source. RT-qPCR and Western blot were used to detect CCND2 expression in normal human thyroid cell line Nthy-ori-3-1 and human PTC cell lines TPC-1 and BCPAP. CCND2 expression was also detected in clinical specimens of PTC and adjacent tissues by immunohistochemistry, and its correlation with clinicopathological features of the patients were analyzed.

resultsInformatic analysis revealed significantly higher CCND2 mRNA expression in thyroid cancer than in the adjacent tissues (

conclusionCCND2 overexpression is closely correlated with tumor progression and immune cell infiltration in PTC patients..

Indexed as

Cyclin D2Thyroid Cancer, PapillaryThyroid NeoplasmsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMaleRNA, MessengerROC CurveCCND2 protein, humanCyclin D2RNA, MessengerbioinformaticsCyclin D2papillary thyroid carcinomatumor immune infiltration

Identifiers

PMID38862457
PMCPMC11166724

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