Evidence map›Paper›PMID 38862438›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Coenzyme Q10 alleviates depression-like behaviors in mice with chronic restraint stress by down-regulating the pyroptosis signaling pathway].

Y Sun, R Zhang, Y Meng, L Zhu, M Li, Z Liu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Y SunDepartment of Pharmacy, First Affiliated Hospital of Bengbu Medical University, Bengbu 233003, China.
R ZhangCollege of Pharmacy, Bengbu Medical University, Bengbu 233003, China.
Y MengCollege of Pharmacy, Bengbu Medical University, Bengbu 233003, China.
L ZhuCollege of Pharmacy, Bengbu Medical University, Bengbu 233003, China.
M LiCollege of Pharmacy, Bengbu Medical University, Bengbu 233003, China.
Z LiuDepartment of Pharmacy, First Affiliated Hospital of Bengbu Medical University, Bengbu 233003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the neuroprotective effect of coenzyme Q10 and its possible mechanism in mice with chronic restraint stress (CRS).

methodsMouse models of CRS were treated with intraperitoneal injections of coenzyme Q10 at low, moderate and high doses (50, 100 and 200 mg/kg, respectively,

resultsCompared with the normal control mice, the mouse models of CRS showed significantly reduced sugar water preference and increased immobility time in forced swimming and tail suspension tests (

conclusionCoenzyme Q10 can alleviate depression-like behaviors in mice with CRS by down-regulating the pyroptosis signaling pathway.

Indexed as

DepressionDisease Models, AnimalHippocampusPyroptosisRestraint, PhysicalSignal TransductionStress, PsychologicalUbiquinoneAnimalsBehavior, AnimalCaspase 1Down-RegulationGlial Fibrillary Acidic ProteinMaleMiceNeuroprotective AgentsCaspase 1coenzyme Q10Glial Fibrillary Acidic ProteinNeuroprotective AgentsUbiquinonecaspase-1chronic restraint stresscoenzyme Q10depressionpyroptosis

Identifiers

PMID38862438
PMCPMC11166719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.