Evidence map›Paper›PMID 38862182›Full record

ArticleStroke and vascular neurology2025

Left atrial appendage closure in patients with atrial fibrillation and acute ischaemic stroke despite anticoagulation.

Avia Abramovitz Fouks, Shadi Yaghi, Magdy H Selim, Elif Gökçal, Alvin S Das, Ofer Rotschild, Scott B Silverman, Aneesh B Singhal, Sunil Kapur, Steven M Greenberg and 1 more

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In one paragraph

Article in Stroke and vascular neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
  4. All for one or one for all!REC, interventional cardiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Avia Abramovitz FouksNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0009-0005-7483-8193
Shadi YaghiNeurology, Brown University, Warren Alpert Medical School, Providence, RI, USA.
Magdy H SelimNeurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Elif GökçalNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Alvin S DasNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2313-977X
Ofer RotschildNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Scott B SilvermanNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Aneesh B SinghalNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Sunil KapurDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Steven M GreenbergNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Mahmut Edip GurolNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA MEGUROL@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe occurrence of acute ischaemic stroke (AIS) while using oral anticoagulants (OAC) is an increasingly recognised problem among nonvalvular atrial fibrillation (NVAF) patients. We aimed to elucidate the potential role of left atrial appendage closure (LAAC) for stroke prevention in patients with AIS despite OAC use (AIS-despite-OAC).

methodsWe retrospectively collected baseline and follow-up data from consecutive NVAF patients who had AIS-despite-OAC and subsequently underwent endovascular LAAC, between January 2015 and October 2021. The primary outcome measure was the occurrence of AIS after LAAC, and the safety outcome was symptomatic intracerebral haemorrhage (ICH).

results29 patients had LAAC specifically because of AIS-despite-OAC. The mean age at the time of the procedure was 73.4±8.7, 13 were female (44.82%). The mean CHA

conclusionsLAAC in AIS-despite-OAC patients demonstrated a low annual AIS recurrence rate in our cohort (1.97%) compared with the expected IR based on their CHA

Indexed as

AnticoagulantsAtrial AppendageAtrial FibrillationCardiac CatheterizationIschemic StrokeAdministration, OralAgedAged, 80 and overCerebral HemorrhageFemaleHumansLeft Atrial Appendage ClosureMaleMiddle AgedRetrospective StudiesRisk AssessmentAnticoagulantsAnticoagulantsAtrial FibrillationEmbolismStroke

Identifiers

PMID38862182
PMCPMC11877432

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