ArticleNeurology2024
Continuous β-Amyloid CSF/PET Imbalance Model to Capture Alzheimer Disease Heterogeneity.
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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed.
- Amyloid-β PET Radioligands in Alzheimer's Disease: From Plaque Detection to Biomarker-Guided Patient Stratification and Therapeutic Monitoring.Molecular diagnosis & therapy · 2026Review
- Regional cerebral hypometabolism and pathological heterogeneity in sporadic early onset alzheimer's disease: China Aging and Neurodegenerative Initiative (CANDI) study.European journal of nuclear medicine and molecular imaging · 2026Article
- Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Trajectories of plasma and CSF MTBR-tau243 and phosphorylated-tau species across the Alzheimer's disease continuum.Nature communications · 2026Article
- Plasma p-tau217 assays effectively predict amyloid status but lack precision for tau staging in Alzheimer's disease.Journal of neurology · 2026Article
- Prospective study on clinical utility of plasma p-Tau217 and other biomarkers in Japanese memory clinics using the LUMIPULSE platform.Alzheimer's research & therapy · 2026Observational
- Blood transcriptomic signatures link β-amyloid deposition to molecular pathways across SCD, MCI, and dementia.Frontiers in aging neuroscience · 2026Article
- A Biomarker-Based Classification of Corticobasal Syndrome.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Concordance between amyloid PET and CSF biomarkers in clinical setting: a cross-platform comparison and in-depth analysis of discordant cases.Scientific reports · 2025Article
- Complementary utility of plasma biomarkers and Aβ-PET for diagnosis, risk-stratification, and treatment monitoring in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Integrated plasma and red blood cell membrane lipidomics analysis unveils novel biomarker panel for Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Targeting Soluble Amyloid Oligomers in Alzheimer's Disease: A Hypothetical Model Study Comparing Intrathecal Pseudodelivery of mAbs Against Intravenous Administration.Diseases (Basel, Switzerland) · 2025Article
- Integrating genetic and immune profiles for personalized immunotherapy in Alzheimer's disease.Frontiers in medicine · 2025Review
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Authors and funding
23 authors.
Sophie E MastenbroekFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0009-0006-2759-9588
Arianna SalaFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
David Vállez GarcíaFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0003-3308-3167
Mahnaz ShekariFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Gemma SalvadóFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Luigi LorenziniFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Leonard PieperhoffFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Alle Meije WinkFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0002-8197-0118
Isadora Lopes AlvesFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Robin WolzFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Craig RitchieFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Mercè BoadaFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0003-2617-3009
Pieter Jelle VisserFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0001-8008-9727
Marco BucciFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Gill FarrarFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0002-0726-723X
Oskar HanssonFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0001-8467-7286
Agneta K NordbergFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0001-7345-5151
Rik OssenkoppeleFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0003-1584-7477
Frederik BarkhofFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0003-3543-3706
Juan Domingo GispertFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0002-6155-0642
Elena Rodriguez-VieitezFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0002-6639-8141
Lyduine E CollijFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.ORCID 0000-0001-6263-1762
Alzheimer's Disease Neuroimaging Initiative on behalf of the AMYPAD consortiumFrom the Department of Radiology and Nuclear Medicine (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc; Amsterdam Neuroscience (S.E.M., D.V.G., L.L., L.P., A.M.W., F.B., L.E.C.), Brain Imaging, the Netherlands; Clinical Memory Research Unit (S.E.M., G.S., O.H., R.O., L.E.C.), Department of Clinical Sciences Malmö, Lund University; Division of Clinical Geriatrics (A.S., M. Bucci, A.K.N., E.R.-V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Coma Science Group (A.S.), GIGA-Consciousness, University of Liège; Centre du Cerveau2 (A.S.), University Hospital of Liège, Belgium; Barcelonaβeta Brain Research Center (BBRC) (M.S., G.S., J.D.G.), Pasqual Maragall Foundation; IMIM (Hospital del Mar Medical Research Institute) (M.S., J.D.G.), Barcelona; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (M.S., J.D.G.), Instituto de Salud Carlos III, Madrid; Universitat Pompeu Fabra (M.S.), Barcelona, Spain; Brain Research Center (I.L.A.), Amsterdam, the Netherlands; IXICO (R.W.), London; Centre for Clinical Brain Sciences (C.R.), University of Edinburgh, United Kingdom; Ace Alzheimer Center Barcelona (M. Boada), Universitat Internacional de Catalunya, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED) (M. Boada), Instituto de Salud Carlos III, Madrid, Spain; Alzheimer Center Amsterdam (P.J.V., R.O.), Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc; Amsterdam Neuroscience (P.J.V.), Neurodegeneration; Alzheimer Center Limburg (P.J.V.), School for Mental Health and Neuroscience, Maastricht University, the Netherlands; Division of Neurogeriatrics (P.J.V.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Theme Inflammation and Aging (M. Bucci, A.K.N.), Karolinska University Hospital, Stockholm, Sweden; GE Healthcare (G.F.), Amersham, United Kingdom; Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden; and Centre for Medical Image Computing (F.B.), and Queen Square Institute of Neurology, UCL, London, United Kingdom.
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MNIA NIH HHS U01 AG024904
Abstract
BACKGROUND AND
objectivesDiscordance between CSF and PET biomarkers of β-amyloid (Aβ) might reflect an imbalance between soluble and aggregated species, possibly reflecting disease heterogeneity. Previous studies generally used binary cutoffs to assess discrepancies in CSF/PET biomarkers, resulting in a loss of information on the extent of discordance. In this study, we (1) jointly modeled Aβ-CSF/PET data to derive a continuous measure of the imbalance between soluble and fibrillar pools of Aβ, (2) investigated factors contributing to this imbalance, and (3) examined associations with cognitive trajectories.
methodsAcross 822 cognitively unimpaired (n = 261) and cognitively impaired (n = 561) Alzheimer's Disease Neuroimaging Initiative individuals (384 [46.7%] females, mean age 73.0 ± 7.4 years), we fitted baseline CSF-Aβ
resultsThe imbalance model could be fit (pseudo- DISCUSSION: We propose a novel continuous model of Aβ CSF/PET biomarker imbalance, accurately describing heterogeneity in soluble vs aggregated Aβ pools in 2 independent cohorts across the full Aβ continuum. Aβ-aggregation scores were consistently associated with genetic and AD-associated CSF biomarkers, possibly reflecting disease heterogeneity beyond methodological influences.
Indexed as
Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersPositron-Emission TomographyAgedAged, 80 and overCognitive DysfunctionFemaleHumansMaleMiddle AgedPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide Fragments
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