Evidence map›Paper›PMID 38862127›Full record

ArticleACS infectious diseases2024

3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance.

Sovitj Pou, Rolf W Winter, Rozalia A Dodean, Katherine Liebman, Yuexin Li, Michael W Mather, Binod Nepal, Aaron Nilsen, Mason J Handford, Teresa M Riscoe and 12 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Revisiting 2-Substituted-4(1Journal of medicinal chemistry · 2026
    Article
  3. Article
  4. Article
  5. Targeting Mitochondrial Function inInternational journal of molecular sciences · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Sovitj PouVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Rolf W WinterVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Rozalia A DodeanVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0001-5002-4607
Katherine LiebmanVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Yuexin LiVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Michael W MatherDepartment of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States.
Binod NepalDepartment of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States.
Aaron NilsenVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0002-3827-8222
Mason J HandfordDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.
Teresa M RiscoeDepartment of Microbiology and Molecular Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.
Sydney LaxsonVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Payton J KirtleyVaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States.
Maya AleshnickVaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States.
Lev N ZakharovCenter for Advanced Materials Characterization in Oregon (CAMCOR), 1443 E. 13th Avenue, Eugene, Oregon 97403, United States.
Jane X KellyVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0001-8871-0207
Martin J SmilksteinVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Brandon K WilderVaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States.
Sandhya KortagereDepartment of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States.
Akhil B VaidyaDepartment of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States.ORCID 0000-0003-1063-5571
P Holland AldayVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0002-0142-2438
J Stone DoggettVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0002-6098-1520
Michael K RiscoeVA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.ORCID 0000-0002-1343-5279

Funding

ORGANELLE GENOMES OF MALARIAL PARASITESR01AI028398 · NIAID · MCP HAHNEMANN UNIVERSITY · PI AKHIL B VAIDYA · 1989 to 2026
$10.1M
Optimizing ELQs for Treatment and Prevention of MalariaR01AI100569 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Michael Kevin RISCOE · 2014 to 2026
$8.0M
Advancing Fast-acting Antimalarials that Disrupt Na+ Homeostasis in ParasitesR01AI154499 · NIAID · DREXEL UNIVERSITY · PI KORTAGERE, SANDHYA, VAIDYA, AKHIL B · 2020 to 2024
$3.7M
Development of a Sustained Release Injectable Formulation for Long-Term Delivery of ELQsR01AI141412 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI RISCOE, MICHAEL KEVIN · 2019 to 2022
$3.2M
Next Generation ELQs for Treatment and Once-Monthly Protection Against MalariaR01AI182513 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Michael Kevin RISCOE, AKHIL B VAIDYA · 2025 to 2026
$1.2M
BLR&D Research Career Scientist Renewal Award ApplicationIK6BX004857 · VA · PORTLAND VA MEDICAL CENTER · PI Michael Kevin RISCOE · 2020 to 2026
–
Development of the potent anti-malarial and anti-Toxoplasma drug, ELQ-316IK2BX002440 · VA · PORTLAND VA MEDICAL CENTER · PI DOGGETT, JOSEPH STONE · 2014 to 2018
–
Novel Therapeutic Strategies for ELQ-422, a preclinical Toxoplasmosis Drug CandidateI01BX004522 · VA · PORTLAND VA MEDICAL CENTER · PI Joseph Stone Doggett · 2019 to 2026
–
Pharmachin Optimization and TestingI01BX003312 · VA · PORTLAND VA MEDICAL CENTER · PI RISCOE, MICHAEL KEVIN · 2016 to 2025
–
BLRD VA I01 BX003312BLRD VA I01 BX004522BLRD VA IK2 BX002440BLRD VA IK6 BX004857NIAID NIH HHS R01 AI028398NIAID NIH HHS R01 AI100569NIAID NIH HHS R01 AI141412NIAID NIH HHS R01 AI154499NIAID NIH HHS R01 AI182513
6 · The paper itself

Abstract

ELQ-300 is a potent antimalarial drug with activity against blood, liver, and vector stages of the disease. A prodrug,

Indexed as

AntimalarialsPlasmodium falciparumQuinolonesAnimalsFemaleHumansMalariaMalaria, FalciparumMiceProdrugsStructure-Activity RelationshipAntimalarialsProdrugsQuinolonesantimalarial drugnext-generation ELQsoral prophylaxisstructure−activity relationships

Identifiers

PMID38862127
PMCPMC11245370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.