ReviewNature2024
A second space age spanning omics, platforms and medicine across orbits.
Abstract readReview
In one paragraph
Review in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Space biology as a catalyst for the next biotech and longevity revolution.Experimental physiology · 2026Article
- Beyond Earth: Recent Advancements in Microgravity Biomedical and Genetic Research in Saudi Arabia.International journal of molecular sciences · 2026Review
- ibSLS as a biobank for democratizing access to multi-omics data and biospecimens from spaceflight research.Nature communications · 2026Article
- From Collapse to Active Self-Repair: Integrative Multi-Omics and Machine Learning Analysis Map the Hepatic Metabolic Adaption in Response to Simulated Spaceflight Stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Long-term major histocompatibility complex class I suppression in astronauts and clinical implications.Communications biology · 2026Review
- Spaceflight multi-omics reveals vulnerabilities of human germ cell development.Science advances · 2026Article
- Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.Nature reviews. Immunology · 2026Review
- Systematic bibliometric and visualized analysis of global research trends, impact, emerging areas, and hotspots of artificial intelligence in personalized medicine.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Monitoring and modulating interconnected physiological systems in space using portable closed-loop technologies.Frontiers in network physiology · 2026Article
- Integrated Platforms to Further Advance Space Biology Research.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Network physiology in space: vision and perspectives on exploring physiological networks during spaceflight for the benefit of life on earth.Frontiers in network physiology · 2026Article
- Space-Earth connection: How space weather fluctuations impact epigenetic aging in an elderly men cohort from Massachusetts, USA.medRxiv : the preprint server for health sciences · 2025Article
- Adverse Outcome Pathways Applied to Space Radiation Research.Environmental and molecular mutagenesis · 2025Review
- Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging.Cell stem cell · 2025Article
- The GENESTAR manual for biospecimen collection biobanking and omics data generation from commercial space missions.NPJ microgravity · 2025Article
- Science of omics: a molecular space odyssey.Experimental physiology · 2025Article
- Advancing space medicine: a global perspective on in-orbit research and future directions.Military Medical Research · 2025Article
- To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants.Communications biology · 2024Article
- The Space Omics and Medical Atlas (SOMA): new resource for medical research in deep space.MedComm · 2024Article
- Protective alleles and precision healthcare in crewed spaceflight.Nature communications · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
84 authors.
Christopher E MasonDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.ORCID 0000-0002-1850-1642
James GreenMetavisionairies, Oxford, UK.ORCID 0000-0002-4625-9216
Konstantinos I AdamopoulosBlue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Evan E AfshinDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Jordan J BaechleBuck Artificial Intelligence Platform, Buck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0002-4498-6647
Mathias BasnerUnit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-8453-0812
Susan M BaileyDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0001-5595-9364
Luca BielskiDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Josef BorgCentre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.
Joseph BorgCentre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.ORCID 0000-0002-2220-5651
Jared T BroddrickSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0003-4871-4822
Marissa BurkeDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-5647-3358
Andrés CaicedoInstituto de Investigaciones en Biomedicina iBioMed, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
Verónica CastañedaFaculty of Medicine, Universidad de los Andes, Santiago, Chile.
Subhamoy ChatterjeeSouthwest Research Institute, Boulder, CO, USA.
Christopher R ChinDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2140-3197
George ChurchHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-6232-9969
Sylvain V CostesSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0002-8542-2389
Iwijn De VlaminckDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-6085-7311
Rajeev I DesaiIntegrative Neurochemistry Laboratory, Behavioral Biology Program, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.ORCID 0000-0002-4053-5996
Raja DhirSeed Health, Venice, CA, USA.
Juan Esteban DiazData Science Institute, School of Business, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
Sofia M EtlinDepartment of Astrobiology, Cornell University, New York, NY, USA.
Zachary FeinsteinDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
David FurmanBuck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0002-3654-9519
J Sebastian Garcia-MedinaDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Francine Garrett-BakelmanDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Stefania GiacomelloScience for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0003-0738-1574
Anjali GuptaANYg Labs, San Diego, CA, USA.ORCID 0000-0001-8783-5083
Amira HassaninDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Nadia HouerbiDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Iris IrbySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-7371-4317
Emilia JavorskyWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Peter JirakParacelsus Medical University, Salzburg, Austria.
Christopher W JonesUnit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-8173-721X
Khaled Y KamalRedox Biology and Cell Signaling Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-6909-8056
Brian D KangasBehavioral Biology Program, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.ORCID 0000-0002-4597-9801
Fathi KarouiaBlue Marble Institute of Science, Exobiology Branch NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0002-1142-9684
JangKeun KimDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8733-9925
Joo Hyun KimRedox Biology and Cell Signaling Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX, USA.
Ashley S KleinmanDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Try LamJet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA.
John M LawlerRedox Biology and Cell Signaling Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX, USA.
Jessica A LeeSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0002-0250-4064
Charles L LimoliDepartment of Radiation Oncology, University of California, Irvine, CA, USA.
Alexander LucaciDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Matthew MacKayDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
J Tyson McDonaldDepartment of Radiation Medicine, Georgetown University School of Medicine, Washington, D.C., USA.ORCID 0000-0003-4300-6827
Ari M MelnickDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8074-2287
Cem MeydanDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-0663-6216
Jakub MieczkowskiInternational Research Agenda 3P-Medicine Laboratory, Medical University of Gdansk, Gdansk, Poland.ORCID 0000-0002-2091-012X
Masafumi MurataniDepartment of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID 0000-0002-0276-8000
Deena NajjarDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0009-0009-7950-2866
Mariam A OthmanRedox Biology and Cell Signaling Laboratory, Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-3927-9892
Eliah G OverbeyDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2866-8294
Vera PaarDepartment of Internal Medicine II, Division of Cardiology, Paracelsus Medical University, Salzburg, Austria.
Jiwoon ParkDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-0045-1429
Amber M PaulBlue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Adrian PerdyanInternational Research Agenda 3P-Medicine Laboratory, Medical University of Gdansk, Gdansk, Poland.ORCID 0000-0002-5098-4357
Jacqueline ProszynskiDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Robert J ReynoldsUniversity of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0003-1070-8996
April E RoncaSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Kate RubinsNASA Johnson Space Center, Houston, TX, USA.
Krista A RyonDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Lauren M SandersBlue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Patricia Savi GloweBioAstra, Los Angeles, CA, USA.
Yash ShevdeUrsa Biotechnology Corporation, Ursa Bio, New York, NY, USA.
Michael A SchmidtSovaris Aerospace, Boulder, CO, USA.
Ryan T ScottKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.ORCID 0000-0003-0654-5661
Bader ShirahDepartment of Neuroscience, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia.ORCID 0000-0001-6493-2155
Karolina SienkiewiczDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Maria A SierraDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Keith SiewLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK.
Corey A TheriotUniversity of Texas Medical Branch, Galveston, TX, USA.
Braden T TierneyDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-7533-8802
Kasthuri VenkateswaranJet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA.
Jeremy Wain HirschbergDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Stephen B WalshLondon Tubular Centre, Department of Renal Medicine, University College London, London, UK.ORCID 0000-0002-8693-1353
Claire WalterDepartment of Physiology and Biophysics and Tri-Institutional Computational Biology and Medicine Program, Weill Cornell Medicine, New York, NY, USA.
Daniel A WinerBuck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0002-8702-0957
Min YuDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.
Luis ZeaSmead Aerospace Engineering Sciences Department, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-4301-9620
Jaime MateusSpace Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.
Afshin BeheshtiBlue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA. abehesht@broadinstitute.org.ORCID 0000-0003-4643-531X
Funding
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8MVAST Center: Viromes Across Space(s) and TimeU54AG089334 · NIA · STANFORD UNIVERSITY · PI Christopher Edward Mason · 2025 to 2026
$13.3MClinical and Molecular Heterogeneity in the Myelodysplastic SyndromesR01CA249054 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MASON, CHRISTOPHER EDWARD, PARK, CHRISTOPHER Y · 2020 to 2024
$3.5MThe Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3MNCI NIH HHS R01 CA249054NIA NIH HHS T32 AG000266NIA NIH HHS U54 AG089334NIMH NIH HHS R01 MH117406Wellcome Trust
Abstract
The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a 'second space age'. This era is also poised to leverage, for the first time, modern tools and methods of molecular biology and precision medicine, thus enabling precision aerospace medicine for the crews. The applications of these biomedical technologies and algorithms are diverse, and encompass multi-omic, single-cell and spatial biology tools to investigate human and microbial responses to spaceflight. Additionally, they extend to the development of new imaging techniques, real-time cognitive assessments, physiological monitoring and personalized risk profiles tailored for astronauts. Furthermore, these technologies enable advancements in pharmacogenomics, as well as the identification of novel spaceflight biomarkers and the development of corresponding countermeasures. In this Perspective, we highlight some of the recent biomedical research from the National Aeronautics and Space Administration, Japan Aerospace Exploration Agency, European Space Agency and other space agencies, and detail the entrance of the commercial spaceflight sector (including SpaceX, Blue Origin, Axiom and Sierra Space) into aerospace medicine and space biology, the first aerospace medicine biobank, and various upcoming missions that will utilize these tools to ensure a permanent human presence beyond low Earth orbit, venturing out to other planets and moons.
Indexed as
Aerospace MedicineAstronautsMultiomicsSpace FlightBiological Specimen BanksBiomarkersCognitionHumansInternationalityMonitoring, PhysiologicPharmacogeneticsPrecision MedicineBiomarkers
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