Evidence map›Paper›PMID 38862026›Full record

ArticleNature2024

Molecular and physiological changes in the SpaceX Inspiration4 civilian crew.

Christopher W Jones, Eliah G Overbey, Jerome Lacombe, Adrian J Ecker, Cem Meydan, Krista Ryon, Braden Tierney, Namita Damle, Matthew MacKay, Evan E Afshin and 49 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Article
  20. Adverse Outcome Pathways Applied to Space Radiation Research.Environmental and molecular mutagenesis · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

59 authors.

Christopher W Jones *Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-8173-721X
Eliah G Overbey *Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2866-8294
Jerome Lacombe *Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
Adrian J EckerUnit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Cem MeydanDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-0663-6216
Krista RyonDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
Braden TierneyDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-7533-8802
Namita DamleDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
Matthew MacKayDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
Evan E AfshinDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
Jonathan FooxDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
Jiwoon ParkDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-0045-1429
Theodore M NelsonDepartment of Microbiology & Immunology, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-8600-0444
Mir Suhail MohamadTrialX Inc., New York, NY, USA.
Syed Gufran Ahmad ByhaquiTrialX Inc., New York, NY, USA.
Burhan AslamTrialX Inc., New York, NY, USA.
Ummer Akbar TaliTrialX Inc., New York, NY, USA.
Liaqun NisaTrialX Inc., New York, NY, USA.
Priya V MenonTrialX Inc., New York, NY, USA.
Chintan O PatelTrialX Inc., New York, NY, USA.
Sharib A KhanTrialX Inc., New York, NY, USA.
Doug J EbertKBR, Science & Space, Houston, TX, USA.
Aaron EversonKBR, Science & Space, Houston, TX, USA.
Michael C SchubertDepartment of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nabila N AliDepartment of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mallika S SarmaDepartment of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-6693-9382
JangKeun KimDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8733-9925
Nadia HouerbiDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
Kirill GrigorevDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-3628-0123
J Sebastian Garcia MedinaDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
Alexander J SummersCenter for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.ORCID 0000-0002-7372-0610
Jian GuCenter for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
John A AltinThe Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Ali FattahiCenter for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.ORCID 0000-0001-8226-5835
Mohammad I HirzallahDepartments of Neurology and Neurosurgery, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-0542-8025
Jimmy H WuCenter for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
Alexander C StahnUnit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-4030-4944
Afshin BeheshtiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-4643-531X
Remi KlotzDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Veronica OrtizDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Min YuDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Laura PatrasChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Irina MateiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-5712-8430
David LydenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-0193-4131
Ari MelnickDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8074-2287
Neil BanerjeeSpaceX, Hawthorne, CA, USA.ORCID 0000-0002-6825-917X
Sean MullaneSpaceX, Hawthorne, CA, USA.
Ashley S KleinmanDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
Michael LoescheSpaceX, Hawthorne, CA, USA.
Anil S MenonUniversity of Texas, Department of Emergency Medicine, Houston, TX, USA.ORCID 0000-0002-6886-3553
Dorit B DonovielCenter for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
Emmanuel UrquietaCenter for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
Jaime MateusSpaceX, Hawthorne, CA, USA.
Ashot E SargsyanKBR, Science & Space, Houston, TX, USA.
Mark ShelhamerDepartment of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Frederic ZenhausernCenter for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
Eric M BershadDepartments of Neurology and Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Mathias BasnerUnit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. basner@pennmedicine.upenn.edu.ORCID 0000-0002-8453-0812
Christopher E MasonDepartment of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.ORCID 0000-0002-1850-1642

Funding

VAST Center: Viromes Across Space(s) and TimeU54AG089334 · NIA · STANFORD UNIVERSITY · PI Christopher Edward Mason · 2025 to 2026
$13.3M
Clinical and Molecular Heterogeneity in the Myelodysplastic SyndromesR01CA249054 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MASON, CHRISTOPHER EDWARD, PARK, CHRISTOPHER Y · 2020 to 2024
$3.5M
Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantationR01AI151059 · NIAID · CORNELL UNIVERSITY · PI DADHANIA, DARSHANA, DE VLAMINCK, IWIJN · 2020 to 2024
$3.4M
The Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3M
A scalable platform for highly-multiplexed analysis of antibody reactivity from <1uL of bloodU24AI152172 · NIAID · TRANSLATIONAL GENOMICS RESEARCH INST · PI ALTIN, JOHN · 2020 to 2024
$3.3M
Targeted Biomarker Panels and Pre-processing Device for the Rapid Assessment of Radiation Injury in Easily Accessible BiofluidsU01AI148307 · NIAID · GEORGETOWN UNIVERSITY · PI LAIAKIS, EVAGELIA CHRISTOS, ZENHAUSERN, FREDERIC · 2021 to 2025
$2.9M
Insulin Stimulated Production Of Nitric Oxide In Vascular EndotheliumZ01AT000001 · NCCIH · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · PI QUON, MICHAEL J. · 2002 to 2008
$2.4M
Intramural NIH HHS Z01 AT000001NCI NIH HHS R01 CA249054NIAID NIH HHS R01 AI151059NIAID NIH HHS U01 AI148307NIAID NIH HHS U24 AI152172NIA NIH HHS U54 AG089334NIMH NIH HHS R01 MH117406
6 · The paper itself

Abstract

Human spaceflight has historically been managed by government agencies, such as in the NASA Twins Study

Indexed as

Adaptation, PhysiologicalAstronautsSpace FlightAdultCognitionDatabases as TopicFemaleHumansMaleMonitoring, PhysiologicMultiomicsStress, PhysiologicalTime FactorsWeightlessness

Identifiers

PMID38862026
PMCPMC11357997

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.