Evidence map›Paper›PMID 38861981›Full record

ArticleThe American journal of tropical medicine and hygiene2024

Close Proximity to Mining Is Associated with Increased Prevalence of the Drug Resistance-Associated Mutation dhps540E in Eastern Democratic Republic of the Congo.

Cedar L Mitchell, Mark M Janko, Robert Verity, Melchior M Kashamuka, Jeffrey A Bailey, Antoinette K Tshefu, Jonathan B Parr, Jonathan J Juliano

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In one paragraph

Article in The American journal of tropical medicine and hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cedar L MitchellDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.
Mark M JankoDuke Global Health Institute, Duke University, Durham, North Carolina.
Robert VerityMedical Research Council Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.
Melchior M KashamukaKinshasa School of Public Health, Kinshasa University, Kinshasa, Democratic Republic of the Congo.
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island.
Antoinette K TshefuKinshasa School of Public Health, Kinshasa University, Kinshasa, Democratic Republic of the Congo.
Jonathan B ParrDivision of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Jonathan J JulianoDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.

Funding

Training in Infectious Disease Epidemiology (TIDE)T32AI070114 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian W Pence · 2007 to 2026
$4.0M
Tracking the flow of malaria parasites and drug resistance within the DRC and across its bordersR01AI139520 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BAILEY, JEFFREY A. · 2018 to 2023
$3.6M
Improving Response to Malaria Outbreaks in Amazon-Basin CountriesR01AI151056 · NIAID · DUKE UNIVERSITY · PI PAN, WILLIAM KUANG-YAO · 2021 to 2025
$3.4M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
Diversity and Phenotype of Artemisinin Resistance Mutations in Central AfricaR21AI121465 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J · 2016 to 2017
$438k
Medical Research Council MR/R015600/1NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI139520NIAID NIH HHS R01 AI151056NIAID NIH HHS R21 AI121465NIAID NIH HHS T32 AI070114
6 · The paper itself

Abstract

Increasing sulfadoxine-pyrimethamine (SP) resistance in the Democratic Republic of the Congo (DRC) has threatened its use for prevention of malaria in one of the most malarious countries in the world. Using geographic information on mining operations in the DRC and genetic data on SP drug resistance markers from the 2013-2014 Demographic and Health Surveys, we evaluated associations between close residence to mining and the presence of mutations conferring resistance to sulfadoxine. Close residential proximity to mining was associated with increased prevalence odds ratio (POR) of the dhps540E mutation (POR: 2.11, 95% uncertainty interval: 1.15-3.96) with adjustments for confounding variables and space. Our findings indicate that exposure to mining is associated with increased presence of an antimalarial drug resistance haplotype that threatens effective use of SP for vulnerable populations. Areas actively engaged in mining could be considered for interventions to reduce the spread of emerging drug resistance in the DRC.

Indexed as

AntimalarialsDrug ResistanceMiningMutationPyrimethamineSulfadoxineDemocratic Republic of the CongoDihydropteroate SynthaseDrug CombinationsFemaleHumansMalaria, FalciparumPlasmodium falciparumPrevalenceAntimalarialsDihydropteroate SynthaseDrug Combinationsfanasil, pyrimethamine drug combinationPyrimethamineSulfadoxine

Identifiers

PMID38861981
PMCPMC11310628

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.