ArticleHormone research in paediatrics2025
Timing of Meal Consumption on Glucose Profiles in Latino Adolescents with Obesity.
Article in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Intermittent fasting as a treatment for obesity in young people: a scoping review.npj metabolic health and disease · 2024Article
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6 authors.
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Abstract
introductionTo date, there has been no study investigating how meal-timing impacts glucose and insulin resistance among Latino youth at high risk of type 2 diabetes. A proof-of-concept study was conducted to assess metabolic response to a test-meal consumed in the morning, afternoon, and evening among 15 Latino adolescents with obesity using a within-participant design.
methodsYouth, 13-19 years of age, with obesity, consumed the same test-meal after a 16 h fast at three different times on separate days. Immediately after consumption of the test meal, a mixed meal tolerance test (MMTT) was performed. The co-primary outcomes were the area under the curve (AUC) for glucose, insulin, and C-peptide, and insulinogenic index (IGI).
resultsTwenty-two youth consented to participate for a 24% recruitment rate (78% female, 100% Latino, mean age 16.5 ± 1.3 years, 70% publicly insured). There was a significantly greater rise in glucose and c-peptide levels following at 4:00 p.m. compared to 8:00 a.m. (glucose: p = 0.006; C-peptide: p < 0.0001) with no significant association found between insulin levels and timing of meal consumption. Pairwise comparisons showed a greater rise in AUC glucose and C-peptide levels at 4:00 p.m. compared to 8:00 a.m. (glucose p = 0.003; C-peptide p < 0.001) with no significant association found between insulin AUC and timing of meal consumption (p = 0.09). There was a greater reduction in IGI at 4:00 p.m. compared to 8:00 a.m. (p = 0.027).
conclusionSimilar to findings in adults at risk for diabetes, Latino youth with obesity show greater insulin resistance in response to a meal consumed in the afternoon and evening compared to early morning food consumption.
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