Evidence map›Paper›PMID 38861691›Full record

ArticleRadiology and oncology2024

Vertebral body collapse after spine stereotactic body radiation therapy: a single-center institutional experience.

Arsh Issany, Austin J Iovoli, Richard Wang, Rohil Shekher, Sung Jun Ma, Victor Goulenko, Fatemeh Fekrmandi, Dheerendra Prasad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology and oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arsh IssanyJacobs School of Medicine and Biomedical Sciences, University at Buffalo, New York, USA.
Austin J IovoliDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, USA.
Richard WangKirk Kerkorian School of Medicine, University of Nevada, Las Vegas, USA.
Rohil ShekherDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, USA.
Sung Jun MaDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, USA.
Victor GoulenkoDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, USA.
Fatemeh FekrmandiDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, USA.
Dheerendra PrasadDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, USA.

Funding

Summer Research Experiences in Quantitative Cancer Sciences and Emerging TechnologiesR25CA181003 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI PAMELA A HERSHBERGER, Mukund Seshadri · 2014 to 2026
$3.3M
NCI NIH HHS R25 CA181003
6 · The paper itself

Abstract

backgroundSpine stereotactic body radiation therapy (SBRT) for the treatment of metastatic disease is increasingly utilized owing to improved pain and local control over conventional regimens. Vertebral body collapse (VBC) is an important toxicity following spine SBRT. We investigated our institutional experience with spine SBRT as it relates to VBC and spinal instability neoplastic score (SINS). PATIENTS AND

methodsRecords of 83 patients with 100 spinal lesions treated with SBRT between 2007 and 2022 were reviewed. Clinical information was abstracted from the medical record. The primary endpoint was post-treatment VBC. Logistic univariate analysis was performed to identify clinical factors associated with VBC.

resultsMedian dose and number of fractions used was 24 Gy and 3 fractions, respectively. There were 10 spine segments that developed VBC (10%) after spine SBRT. Median time to VBC was 2.4 months. Of the 11 spine segments that underwent kyphoplasty prior to SBRT, none developed subsequent VBC. No factors were associated with VBC on univariate analysis.

conclusionsThe rate of vertebral body collapse following spine SBRT is low. Prophylactic kyphoplasty may provide protection against VBC and should be considered for patients at high risk for fracture.

Indexed as

RadiosurgerySpinal NeoplasmsAdultAgedAged, 80 and overFemaleHumansKyphoplastyMaleMiddle AgedRetrospective StudiesSpinal FracturesVertebral Bodykyphoplastyspinal instabilityspine metastasisstereotactic body radiation therapyvertebral compression fracture

Identifiers

PMID38861691
PMCPMC11406905

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.