ArticleProceedings of the National Academy of Sciences of the United States of America2024
Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Cascading Periods of Language-Related Brain Plasticity Across Early Childhood.Developmental science · 2026Article
- Metabolic organization of macaque visual cortex reflects visual field topography and perceptual specialization.PLoS biology · 2026Article
- Cascading periods of language-related brain plasticity across early childhood.bioRxiv : the preprint server for biology · 2026Article
- Mesoscale molecular architecture of the human striatum across cell types and lifespan.bioRxiv : the preprint server for biology · 2026Article
- Five energy metabolism pathways show distinct regional distributions and lifespan trajectories in the human brain.PLoS biology · 2026Article
- Simultaneous generation of transplantable RGC-like and corneal progenitor cells from hiPSCs using a dual-lineage platform.Stem cell research & therapy · 2025Article
- Brain-AI Alignment in Naturalistic Movies.bioRxiv : the preprint server for biology · 2025Article
- Structural similarity networks reveal brain vulnerability in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Growth and development of the precuneus in humans from birth to early adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- Maturation of Neuronal Activity in the Human Cortex Exhibits Robust Spatial Gradients across the Birth Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cerebral cortical structures linked to intelligence.bioRxiv : the preprint server for biology · 2025Article
- Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A multimodal characterization of low-dimensional thalamocortical structural connectivity patterns.Communications biology · 2025Article
- Perinatal development of structural thalamocortical connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Transcriptomic gradients of the human cerebellum.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neuron identity switches in response to the gradient gene expression pathway.Frontiers in cellular neuroscience · 2025Article
- Article
- A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients.bioRxiv : the preprint server for biology · 2023Article
- Mapping the movie-watching brain with AI-derived semantics.Imaging neuroscience (Cambridge, Mass.)Article
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14 authors.
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Abstract
Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, whether similar gradients are maintained in the adult brain remains unknown. Here, we uncover three axes of topographic variation in gene expression in the adult human brain that specifically capture previously identified rostral-caudal, dorsal-ventral, and medial-lateral axes of early developmental patterning. The interaction of these spatiomolecular gradients i) accurately reconstructs the position of brain tissue samples, ii) delineates known functional territories, and iii) can model the topographical variation of diverse cortical features. The spatiomolecular gradients are distinct from canonical cortical axes differentiating the primary sensory cortex from the association cortex, but radiate in parallel with the axes traversed by local field potentials along the cortex. We replicate all three molecular gradients in three independent human datasets as well as two nonhuman primate datasets and find that each gradient shows a distinct developmental trajectory across the lifespan. The gradients are composed of several well-known transcription factors (e.g.,
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