Evidence map›Paper›PMID 38861288›Full record

ReviewFuture oncology (London, England)2024

Treatment options for biliary tract cancer: unmet needs, new targets and opportunities from both physicians' and patients' perspectives.

Rachna T Shroff, Melinda Bachini

Abstract readReview
In one paragraph

Review in Future oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. ESMO gastrointestinal oncology · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rachna T ShroffUniversity of Arizona Cancer Center, University of Arizona, Tucson, AZ 85719, USA.ORCID 0000-0003-0066-2672
Melinda BachiniCholangiocarcinoma Foundation, 5526 West 13400 South, #510, Herriman, UT USA.

Funding

Boehringer Ingelheim
6 · The paper itself

Abstract

Biliary tract cancer (BTC) is a rare cancer with poor prognosis, characterized by considerable pathophysiological and molecular heterogeneity. While this makes it difficult to treat, it also provides targeted therapy opportunities. Current standard-of-care is chemotherapy ± immunotherapy, but several targeted agents have recently been approved. The current investigational landscape in BTC emphasizes the importance of biomarker testing at diagnosis. MDM2/MDMX are important negative regulators of the tumor suppressor p53 and provide an additional target in BTC (∼5-8% of tumors are

Indexed as

Biliary Tract NeoplasmsMolecular Targeted TherapyAntineoplastic AgentsBiomarkers, TumorCell Cycle ProteinsHumansImmunotherapyProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53Antineoplastic AgentsBiomarkers, TumorCell Cycle ProteinsMDM2 protein, humanMDM4 protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53BI 90782823biliary tract cancerbrigimadlinMDM2–p53plain-language summarytargeted therapy

Identifiers

PMID38861288
PMCPMC11376410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.