Evidence map›Paper›PMID 38861067›Full record

ArticleVisual computing for industry, biomedicine, and art2024

Simulated deep CT characterization of liver metastases with high-resolution filtered back projection reconstruction.

Christopher Wiedeman, Peter Lorraine, Ge Wang, Richard Do, Amber Simpson, Jacob Peoples, Bruno De Man

Abstract read
In one paragraph

Article in Visual computing for industry, biomedicine, and art, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher WiedemanDepartment of Electrical and Computer Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Peter LorraineGE Research - Healthcare, Niskayuna, NY, 12309, USA.
Ge WangDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.ORCID http://orcid.org/0000-0002-2656-7705
Richard DoDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Amber SimpsonBiomedical Computing and Informatics, Queen's University, Kingston, ON, K7L 3N6, Canada.
Jacob PeoplesBiomedical Computing and Informatics, Queen's University, Kingston, ON, K7L 3N6, Canada.
Bruno De ManGE Research - Healthcare, Niskayuna, NY, 12309, USA. deman@ge.com.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Development and Validation of Prognostic Radiomic Markers of Response and Recurrence for Patients with Colorectal Liver MetastasesR01CA233888 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHUN, YUN SHIN, DO, RICHARD KINH GIAN · 2019 to 2023
$3.7M
National Science Foundation Graduate Research Fellowship Program DGE2147721NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA233888NIBIB NIH HHS R01CA233888
6 · The paper itself

Abstract

Early diagnosis and accurate prognosis of colorectal cancer is critical for determining optimal treatment plans and maximizing patient outcomes, especially as the disease progresses into liver metastases. Computed tomography (CT) is a frontline tool for this task; however, the preservation of predictive radiomic features is highly dependent on the scanning protocol and reconstruction algorithm. We hypothesized that image reconstruction with a high-frequency kernel could result in a better characterization of liver metastases features via deep neural networks. This kernel produces images that appear noisier but preserve more sinogram information. A simulation pipeline was developed to study the effects of imaging parameters on the ability to characterize the features of liver metastases. This pipeline utilizes a fractal approach to generate a diverse population of shapes representing virtual metastases, and then it superimposes them on a realistic CT liver region to perform a virtual CT scan using CatSim. Datasets of 10,000 liver metastases were generated, scanned, and reconstructed using either standard or high-frequency kernels. These data were used to train and validate deep neural networks to recover crafted metastases characteristics, such as internal heterogeneity, edge sharpness, and edge fractal dimension. In the absence of noise, models scored, on average, 12.2% (

Indexed as

Colorectal liver metastasesComputed tomographyDeep learningImage reconstructionRadiomicsVirtual clinical trials

Identifiers

PMID38861067
PMCPMC11166620

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.