Evidence map›Paper›PMID 38860855›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach.

Omkar N Athavale, Madeleine R Di Natale, Recep Avci, Alys R Clark, John B Furness, Leo K Cheng, Peng Du

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Omkar N AthavaleAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.ORCID 0000-0003-0144-8053
Madeleine R Di NataleFlorey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.ORCID 0000-0002-7949-5725
Recep AvciAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.ORCID 0000-0003-2652-2192
Alys R ClarkAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.ORCID 0000-0001-5908-2862
John B FurnessFlorey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.ORCID 0000-0002-0219-3438
Leo K ChengAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.ORCID 0000-0003-2426-8987
Peng DuAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-6913-7545

Funding

The Virtual StomachOT2OD030538 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHENG, LEO, LIU, ZHONGMING · 2020 to 2021
$1.7M
HHS | NIH | NIH Office of the Director (OD) OT2OD030538Ministry of Business, Innovation and Employment (MBIE) Catalyst: Strategic fundNIH HHS OT2 OD030538Royal Society Te Apārangi (Royal Society of New Zealand) Marsden Fund CouncilUniversity of Auckland (UoA) Doctoral Scholarship
6 · The paper itself

Abstract

Rhythmic electrical events, termed slow waves, govern the timing and amplitude of phasic contractions of the gastric musculature. Extracellular multielectrode measurement of gastric slow waves can be a biomarker for phenotypes of motility dysfunction. However, a gastric slow-wave conduction pathway for the rat, a common animal model, is unestablished. In this study, the validity of extracellular recording was demonstrated in vitro with simultaneous intracellular and extracellular recordings and by pharmacological inhibition of slow waves. The conduction pathway was determined by in vivo extracellular recordings while considering the effect of motion. Slow-wave characteristics [means (SD)] varied regionally having higher amplitude in the antrum than the distal corpus [1.03 (0.12) mV vs. 0.75 (0.31) mV;

Indexed as

Gastrointestinal MotilityMuscle, SmoothRats, Sprague-DawleyStomachAnimalsInterstitial Cells of CajalMaleMuscle ContractionPyloric AntrumRatsextracellular recordinggastric electrophysiologygastric motilityinterstitial cells of Cajalintracellular recording

Identifiers

PMID38860855
PMCPMC11427108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.