Evidence map›Paper›PMID 38860826›Full record

Trial reportMicrobiology spectrum2024

Novel probiotic preparation with

Olga Nikoloudaki, Giuseppe Celano, Andrea Polo, Claudia Cappello, Lena Granehäll, Alice Costantini, Mirco Vacca, Bodo Speckmann, Raffaella Di Cagno, Ruggiero Francavilla and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Olga NikoloudakiFaculty of Agricultural, Environmental and Food Sciences, Free University of Bozen-Bolzano, Bolzano, Italy.ORCID 0000-0002-2985-9033
Giuseppe CelanoDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.ORCID 0000-0002-3805-7681
Andrea PoloFaculty of Agricultural, Environmental and Food Sciences, Free University of Bozen-Bolzano, Bolzano, Italy.ORCID 0000-0002-3001-4927
Claudia CappelloFaculty of Agricultural, Environmental and Food Sciences, Free University of Bozen-Bolzano, Bolzano, Italy.
Lena GranehällFaculty of Agricultural, Environmental and Food Sciences, Free University of Bozen-Bolzano, Bolzano, Italy.
Alice CostantiniFaculty of Agricultural, Environmental and Food Sciences, Free University of Bozen-Bolzano, Bolzano, Italy.
Mirco VaccaDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Bodo SpeckmannEvonik Operations GmbH, Creavis, Essen, Germany.
Raffaella Di CagnoFaculty of Agricultural, Environmental and Food Sciences, Free University of Bozen-Bolzano, Bolzano, Italy.ORCID 0000-0002-9431-4427
Ruggiero FrancavillaInterdisciplinary Department of Medicine-Pediatric Section, University of Bari Aldo Moro, Ospedale Pediatrico Giovanni XXIII, Bari, Italy.
Maria De AngelisDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Marco GobbettiFaculty of Agricultural, Environmental and Food Sciences, Free University of Bozen-Bolzano, Bolzano, Italy.ORCID 0000-0003-0869-2737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gluten possesses unique properties that render it only partially digestible. Consequently, it exerts detrimental effects on a part of the worldwide population who are afflicted with celiac disease (1%) or related disorders (5%), particularly due to the potential for cross-contamination even when adhering to a gluten-free diet (GFD). Finding solutions to break down gluten during digestion has a high nutritional and social impact. Here, a randomized double-blind placebo-controlled IMPORTANCE: The untapped potential of gluten-degrading bacteria and their application in addressing the recognized limitations of gluten-related disorder management and the ongoing risk of cross-contamination even when people follow a gluten-free diet (GFD) emphasizes the significance of the work. Because gluten, a common protein found in many cereals, must be strictly avoided to stop autoimmune reactions and related health problems, celiac disease and gluten sensitivity present difficult hurdles. However, because of the hidden presence of gluten in many food products and the constant danger of cross-contamination during food preparation and processing, total avoidance is frequently challenging. Our study presents a novel probiotic preparation suitable for people suffering from gluten-related disorders during GFD and for healthy individuals because it enhances gluten digestion and promotes gut microbiota functionality.

Indexed as

FecesGastrointestinal MicrobiomeGlutensProbioticsAdultBacillusCeliac DiseaseDiet, Gluten-FreeDouble-Blind MethodFemaleHumansLactobacillusMaleMiddle AgedYoung AdultGlutensBacillus sp.celiac diseasedigestionfecal metabolomeglutengluten-free diet (GFD)lactobacilliprobioticqPCRresidual gluten

Identifiers

PMID38860826
PMCPMC11218521

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.