Evidence map›Paper›PMID 38860823›Full record

ArticlemBio2024

Skeletal muscle mitochondrial dysfunction mediated by

Shifu Aggarwal, Vijay Singh, Arijit Chakraborty, Sujin Cha, Alexandra Dimitriou, Claire de Crescenzo, Olivia Izikson, Lucy Yu, Roberto Plebani, A Aria Tzika and 1 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Revealing the impact ofFrontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Shifu AggarwalDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9671-8257
Vijay SinghDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Arijit ChakrabortyDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sujin ChaDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Alexandra DimitriouDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-5572-5450
Claire de CrescenzoDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Olivia IziksonDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lucy YuDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Roberto PlebaniDepartment of Medical, Oral and Biotechnological Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
A Aria TzikaDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Laurence G RahmeDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-5374-4332

Funding

Molecular and Metabolic inter-kingdom actions of a bacterial quorum sensing signal in promotion of host tolerance/resilience.R01AI134857 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2018 to 2022
$3.4M
A comprehensive investigation of Pseudomonas quorum sensing regulatory relationships and the consequences on quorum sensing inhibitors in complex communitiesR01AI177555 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LAURENCE G RAHME · 2023 to 2026
$3.4M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI134857HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI177555NIAID NIH HHS R01 AI134857NIAID NIH HHS R01 AI177555
6 · The paper itself

Abstract

Sepsis and chronic infections with IMPORTANCE: Skeletal muscle, pivotal for many functions in the human body, including breathing and protecting internal organs, contains abundant mitochondria essential for maintaining cellular homeostasis during infection. The effect of

Indexed as

Bacterial ProteinsMuscle, SkeletalPseudomonas aeruginosaPseudomonas InfectionsQuorum SensingAdenosine TriphosphateAnimalsAnti-Bacterial AgentsDisease Models, AnimalMaleMiceMice, Inbred C57BLMitochondriaMitochondria, MuscleOligopeptidesOxidative PhosphorylationAdenosine TriphosphateAnti-Bacterial Agentsarginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamideBacterial ProteinsOligopeptidesReactive Oxygen SpeciesTranscription FactorsVirulence FactorsATPbioenergeticsinfectionmetabolismmitochondrial dysfunctionmitochondrionmitophagyMvfRoxidative phosphorylationPA14PqsRPseudomonas aeruginosaquorum sensingROSskeletal muscle

Identifiers

PMID38860823
PMCPMC11253625

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.