Evidence map›Paper›PMID 38860795›Full record

ArticleMicrobiology spectrum2024

Interruption of mycothiol synthesis and intracellular redox status impact iron-regulated reporter activation in

Alexandra H Miller, Frances Marks, Luming Chan, Helene Botella, Dirk Schnappinger, Sabine Ehrt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexandra H MillerDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.ORCID 0000-0001-8104-0554
Frances MarksDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Luming ChanDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Helene BotellaDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Dirk SchnappingerDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.ORCID 0000-0002-4445-7219
Sabine EhrtDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.ORCID 0000-0002-7951-2310

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Conditional Expression of Mycobacterial GenesR01AI063446 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI EHRT, SABINE · 2006 to 2022
$7.2M
Ironing out mycobacterial persistence: Iron access and utilization in chronic mycobacterial infectionF30HL151085 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MILLER, ALEXANDRA HALEY · 2020 to 2023
$194k
Investigating genetic regulators of Mycobacterium tuberculosis cell division and their role in persistent tuberculosis infectionF31AI169872 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARKS, FRANCES · 2023 to 2024
$97k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F31 Al169872NHLBI NIH HHS F30 HL151085NIAID NIH HHS R01 AI063446NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Iron scavenging is required for full virulence of mycobacterial pathogens. During infection, the host immune response restricts mycobacterial access to iron, which is essential for bacterial respiration and DNA synthesis. The

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialGenes, ReporterGlycopeptidesInositolIronMycobacterium smegmatisOxidation-ReductionCysteineDNA Transposable ElementsMycobacterium tuberculosisPromoter Regions, GeneticRepressor ProteinsBacterial ProteinsCysteineDNA Transposable ElementsGlycopeptidesIdeR protein, Mycobacterium tuberculosisInositolIronmycothiolRepressor Proteinsiron regulationMycobacteriummycothiolpromoters

Identifiers

PMID38860795
PMCPMC11218476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.