ArticleMedical physics2024
Quantitative, real-time scintillation imaging for experimental comparison of different dose and dose rate estimations in UHDR proton pencil beams.
Article in Medical physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Experimental characterization of proton minibeam therapy delivery under FLASH dose-rate conditions.Scientific reports · 2026Article
- Ultra-fast dosimetric data collection with a commercial plastic scintillation detector in an MR-linac.Journal of applied clinical medical physics · 2026Article
- Wide area surface dosimetry with conformal scintillator array for external beam radiotherapy.Medical physics · 2026Article
- High-resolution scintillation imaging for detecting delivery errors in preclinical ultrahigh dose rate proton beam therapy.Medical physics · 2026Article
- Pulse-by-pulse ultra-high resolution scintillation imaging of proton FLASH beams produced by a gantry-mounted synchrocyclotron.Physics in medicine and biology · 2025Article
- Advancing Proton Therapy: Integration of Minibeam Spatial Fractionation and FLASH Dose Rates.Research square · 2025Article
- Emulating Clinical Workflow of Scintillator Array Dosimetry for FLASH Pencil-Beam Scanning Proton Therapy.International journal of radiation oncology, biology, physics · 2025Article
- Quality assurance and reporting for FLASH clinical trials: The experience of the FEATHER trial.Medical physics · 2025Article
- Design and characterization of a novel scintillator array for UHDR PBS proton therapy surface dosimetry.Medical physics · 2025Article
- Imaging system for real-time, full-field pulse-by-pulse surface dosimetry of UHDR electron beams.Medical physics · 2025Article
- First Retrospective QA of FAST-01 Clinical Treatment Fields Using High-Speed Quantitative Scintillation Imaging.International journal of radiation oncology, biology, physics · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundUltra-high dose rate radiotherapy (UHDR-RT) has demonstrated normal tissue sparing capabilities, termed the FLASH effect; however, available dosimetry tools make it challenging to characterize the UHDR beams with sufficiently high concurrent spatial and temporal resolution. Novel dosimeters are needed for safe clinical implementation and improved understanding of the effect of UHDR-RT. PURPOSE: Ultra-fast scintillation imaging has been shown to provide a unique tool for spatio-temporal dosimetry of conventional cyclotron pencil beam scanning (PBS) deliveries, indicating the potential use for characterization of UHDR PBS proton beams. The goal of this work is to introduce this novel concept and demonstrate its capabilities in recording high-resolution dose rate maps at FLASH-capable proton beam currents, as compared to log-based dose rate calculation, internally developed UHDR beam simulation, and a fast point detector (EDGE diode).
methodsThe light response of a scintillator sheet located at isocenter and irradiated by PBS proton fields (40-210 nA, 250 MeV) was imaged by an ultra-fast iCMOS camera at 4.5-12 kHz sampling frequency. Camera sensor and image intensifier gain were optimized to maximize the dynamic range; the camera acquisition rate was also varied to evaluate the optimal sampling frequency. Large field delivery enabled flat field acquisition for evaluation of system response homogeneity. Image intensity was calibrated to dose with film and the recorded spatio-temporal data was compared to a PPC05 ion chamber, log-based reconstruction, and EDGE diode. Dose and dose rate linearity studies were performed to evaluate agreement under various beam conditions. Calculation of full-field mean and PBS dose rate maps were calculated to highlight the importance of high resolution, full-field information in UHDR studies.
resultsCamera response was linear with dose (R
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