Evidence map›Paper›PMID 38860458›Full record

ArticleGut microbes

Association between gut microbiota and CpG island methylator phenotype in colorectal cancer.

Pyoung Hwa Park, Kelsey Keith, Gennaro Calendo, Jaroslav Jelinek, Jozef Madzo, Raad Z Gharaibeh, Jayashri Ghosh, Carmen Sapienza, Christian Jobin, Jean-Pierre J Issa

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  11. Article
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  14. Frontiers in microbiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pyoung Hwa ParkFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0002-5850-6181
Kelsey KeithFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0002-7451-5117
Gennaro CalendoResearch, Coriell Institute for Medical Research, Camden, NJ, USA.ORCID 0000-0002-4510-5530
Jaroslav JelinekFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0002-2533-0220
Jozef MadzoFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0001-6607-1213
Raad Z GharaibehDepartment of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-5484-8902
Jayashri GhoshFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0002-4929-5829
Carmen SapienzaFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0003-2194-0344
Christian JobinDepartment of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-3733-1001
Jean-Pierre J IssaFels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0003-2258-5030

Funding

Pathology CoreP50CA254897 · NCI · CORIELL INSTITUTE FOR MEDICAL RESEARCH · PI ISSA, JEAN-PIERRE J. · 2021 to 2025
$11.9M
TUFCCC/HC Regional Comprehensive Cancer Health PartnershipU54CA221704 · NCI · HUNTER COLLEGE · PI Ming-Chin Yeh · 2018 to 2026
$10.6M
Role of the microbiota in DNA methylation and CRC developmentR01CA214005 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI ISSA, JEAN-PIERRE J., JOBIN, CHRISTIAN · 2018 to 2022
$2.9M
Are racial disparities in colon cancer due to epigenetic outliers.R21CA264213 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI GHOSH, JAYASHRI, SAPIENZA, CARMEN · 2021 to 2022
$404k
NCI NIH HHS P50 CA254897NCI NIH HHS R01 CA214005NCI NIH HHS R21 CA264213NCI NIH HHS U54 CA221704
6 · The paper itself

Abstract

The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, although the relationship between tumor-infiltrating bacteria and CIMP status is currently unexplored. In this study, we investigated tumor-associated bacteria in 203 CRC tumor cases and validated the findings using The Cancer Genome Atlas datasets. We assessed the abundance of

Indexed as

BacteriaColorectal NeoplasmsCpG IslandsDNA MethylationGastrointestinal MicrobiomeAgedBacteroides fragilisFemaleHumansMaleMiddle AgedPhenotypeColorectal cancerCpG island methylator phenotypeDNA methylationEpigeneticsGut microbiota

Identifiers

PMID38860458
PMCPMC11174071

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.