Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Jacelyn E Peabody LeverDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-3490-8474
K Brett TurnerDivision of Pulmonary Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Courtney M FernandezDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Hui Min LeungWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Shah Saddad HussainDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-6830-2924
Ren-Jay SheiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Vivian Y LinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Susan E BirketDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-6353-6596
Kengyeh K ChuWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Steven M RoweDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0001-9045-0133
George M SolomonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-2969-5518
Funding
UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Steven Mark Rowe · 2007 to 2026
$23.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Translational Program in CFTR-Related Airway DiseasesR35HL135816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROWE, STEVEN MARK · 2017 to 2022
$6.3M
Training Program in Lung Biology and Translational MedicineT32HL105346 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAGGAR, AMIT · 2010 to 2025
$5.0M
The Role of Airway Mucus in Infection and InflammationR01HL153079 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIRKET, SUSAN ELIZABETH · 2021 to 2025
$2.2M
Functional Categorization of Ciliary Motion in PCDK08HL138153 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SOLOMON, GEORGE MARTIN · 2019 to 2023
$799k
Mucus Matters: Mucociliary Physiology in Pulmonary FibrosisF31HL146083 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVER, JACELYN EMILY PEABODY · 2019 to 2020
$77k
Cystic Fibrosis Foundation (CFF) Solomon 20Y0HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1K08HL138153-01A1HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 2T32HL105346-11A1HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5F31HL146083-02HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R35 HL135816-04S1HHS | NIH | National Institute of General Medical Sciences (NIGMS) 3T32GM008361-30S1HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) 2P30DK072482-12NHLBI NIH HHS F31 HL146083NHLBI NIH HHS K08 HL138153NHLBI NIH HHS R01 HL153079NHLBI NIH HHS R35 HL135816NHLBI NIH HHS T32 HL105346NIDDK NIH HHS P30 DK072482NIGMS NIH HHS T32 GM008361
6 · The paper itself
Abstract
The mucociliary transport apparatus is critical for maintaining lung health via the coordinated movement of cilia to clear mucus and particulates. A metachronal wave propagates across the epithelium when cilia on adjacent multiciliated cells beat slightly out of phase along the proximal-distal axis of the airways in alignment with anatomically directed mucociliary clearance. We hypothesized that metachrony optimizes mucociliary transport (MCT) and that disruptions of calcium signaling would abolish metachrony and decrease MCT. We imaged bronchi from human explants and ferret tracheae using micro-optical coherence tomography (µOCT) to evaluate airway surface liquid depth (ASL), periciliary liquid depth (PCL), cilia beat frequency (CBF), MCT, and metachrony in situ. We developed statistical models that included covariates of MCT. Ferret tracheae were treated with BAPTA-AM (chelator of intracellular Ca
Indexed as
CalciumCiliaFerretsMucociliary ClearanceAnimalsBronchiCalcium SignalingHumansMaleTracheaCalciumairway physiologycalcium signalingciliametachronymucociliary transport
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Metachrony drives effective mucociliary transport via a calcium-dependent mechanism. · full record | OpenQuestion